Spatially Transcriptomics Reveals Molecular Signatures in CRPS
- Conditions
- Complex Regional Pain Syndromes
- Registration Number
- NCT05986461
- Lead Sponsor
- Seoul National University
- Brief Summary
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
- Detailed Description
Participants who meet the diagnostic criteria for CRPS, aged 19\~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).
Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10
- Meets the Budapest diagnostic criteria
- Consents to participation in this study
- Aged between 19 and 80 years old
- Symptoms and/or signs of sensory, vasomotor, and sudomotor changes
- Who do not agree to participate in this study
- Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Numerical Rating Scale (NRS) At the time of biopsy Intensity of pain (now, weekly avarege, weekly maximum)
Thermography At the time of diagnosis Thermography of the involved limb
Quantitative Sensory Testing (QST) At the time of diagnosis Vibration Detection Threshold (VDT), Cold Detection Threshold (CDT)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic ofJee Youn Moon, M.D.Principal Investigator