Haploidentical Natural Killer Cells Infusion before Autologous Stem Cell Transplantation in High risk Neuroblastoma

Phase 1

Recruiting

• Conditions: euroblastoma.; Malignant neoplasm of unspecified part of unspecified adrenal gland; C74.90

• Registration Number: IRCT20140818018842N32
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Harvesting and stem cell cryopreservation should be done before admission for HSCT.
Patients should be in complete remission.
Patients must have adequate organ function including hematologic, cardiac, renal, respiratory and liver.
Karnofsky or Lansky performance score of greater than or equal to 50.
Patient has a suitable adult family member donor available for NK cell donation.
At least two weeks since receipt of any biological therapy, systemic chemotherapy, and/or radiation therapy.
1-25 y/o patients with neuroblastoma candidate for auto-hsct

Exclusion Criteria

Active or uncontrolled infection
Patient declines participation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overal survival. Timepoint: 1 year. Method of measurement: CTscan.