Impact of Cytomegalovirus (CMV) Status Prior Antiretroviral Therapy on HIV Viral Load Decay
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 345
- 试验地点
- 1
- 主要终点
- HIV viral load undetectability
研究概览
简要总结
Background: Cytomegalovirus (CMV) infection is usually observed among patients with HIV infection. No study to date has investigated the impact of CMV infection on HIV viral load decay during antiretroviral therapy.
Methods: 345 consecutive HIV patients coinfected (N=300) or not (N=45) with CMV were enrolled. Clinical, biological and virological data were collected from HIV antiretroviral therapy initiation to the day of HIV viral load undetectability if any.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV patients starting an antiretroviral therapy
- •CMV serology available at antiretroviral therapy initiation
- •HIV viral load assessed at each follow-up visit after treatment initiation
排除标准
- •HIV antiretroviral treatment initiation before June 2005
结局指标
主要结局
HIV viral load undetectability
时间窗: From date of HIV therapy initiation until the date of HIV viral load undetectability (12 weeks in average after treatment initiation)
HIV viral load was assessed during the follow-up visits after the initiation of antiretroviral therapy. HIV undetectability was defined by an HIV-RNA level \<50 copies/mL.
次要结局
未报告次要终点