se of transcranial random noise stimulation (tRNS) as an adjunct to reaching training in chronic stroke survivors with severe arm paresis: An exploratory pilot study.
- Conditions
- StrokePhysical Medicine / Rehabilitation - PhysiotherapyStroke - IschaemicStroke - Haemorrhagic
- Registration Number
- ACTRN12614000952640
- Lead Sponsor
- Dr Kathryn Hayward
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 8
All participants will be first time adult (greater than 18 years) stroke survivors who are 6 to 24 months post stroke who demonstrate severe upper limb paresis (as indicated by a Motor Assessment Scale item 6 score of less than 4 out of a possible 6 points). A minimum level of active movement consistent with a triceps brachii score of 2- is required, along with the ability to understand single stage commands. All participants will not have participated in any rehabilitation services for their arm for at least 2-weeks prior to commencement of training.
Exclusion criteria include: 1) any contraindications to tRNS or MRI, 2) presence of neurological conditions other than stroke e.g., Parkinson’s disease, or upper limb comorbidities that could limit functional recovery e.g., arthritis, 3) elbow contracture greater than 15 degrees, or 4) currently taking medication/s that could alter cortical excitability (e.g., antiepileptic medications, antidepressants) or have a presumed positive or negative effect on neural plasticity (e.g., dopamine, dexamphetamine).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite score of Motor Assessment Scale upper limb items 6-8, which measure upper arm function, hand movements and advanced hand movements.[Measured at pre training (week 0), post training (week 4), follow-up (week 12).]
- Secondary Outcome Measures
Name Time Method