Addition of clinidine to articaine solution in pain relief after root canal treatment
Phase 3
- Conditions
- Post operative pain.Other acute postprocedural painG89.18
- Registration Number
- IRCT20201031049199N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Aged 15-60
ASA grade I
Have symptomatic irreversible pulpitis in a mandibular posterior tooth
Exclusion Criteria
necessity for multi-visit treatments
consumption of analgesics or opioids in a week
periodontal problems
underlying diseases such as diabetes, hypertension or other cardiovascular diseases
an allergy or contraindication to clonidine, articaine, or epinephrine
active signs of oral infection or inflammation
Pregnant or lactating mothers
drug abusers, and patients taking a ß-blocker
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score. Timepoint: 12 h after- 24 h after-36 h after- 48 h after-72 h after procedure. Method of measurement: Heft- parker visual analog scale.
- Secondary Outcome Measures
Name Time Method Heart rate. Timepoint: Immediately Before administration- 5 minutes after administration. Method of measurement: digital blood pressure monitor (M3, Omron, omron healthcare co MTD, japan).