Effect of Progesterone Therapy in Cases With Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Number of participants suffering neuronal infarction
研究概览
简要总结
Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .
详细描述
Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Traumatic subarachinoid hemorrhage
排除标准
- •History of malignency
- •History of cerebrovasculer stroke
- •Morbid obese
研究组 & 干预措施
Control
Receiving conventional management for traumatic subarachinoid hemorrhage
干预措施: Progesterone (Drug)
progesterone group
Intramusculer progesterone therapy before and after craniotomy
干预措施: Progesterone (Drug)
结局指标
主要结局
Number of participants suffering neuronal infarction
时间窗: 2 months
Transcranial doppler
次要结局
未报告次要终点
研究者
Mina Maher
Principle investigator
Ministry of Health and Population, Egypt