Evaluation of efficacy of sodium valproate in cervical and lumbar radicular pain management
- Conditions
- cervical and lumbar radicular pain.
- Registration Number
- IRCT201403101836N8
- Lead Sponsor
- Shahid Sadoughi University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion criteria:
1.Diagnosis of lumbar or cervical radicular pain based on diagnostic of rheumatology specialist.
2.Age between 30 and 60 years.
3.Patients will included if they don’t have possibility of health risk or confounding by other diseases of syndromes, e.g., pregnancy, thyroid disorders, hepatic or kidney disorders, congestive heart failure and diabetes mellitus.
4.Patients havent used sodium valproate or if they have been using, they must remember pain intensity before using sodium valproate and can compare with current pain intensity.
5.Weight between 60 and 90 kg.
Exclusion criteria:
1.Intolerance to sodium valproate side effects.
2.Patients will be forced to administerated medicines that change protein binding or clearance of sodium valproate.
3.Patients will be given diseases that affect the results of study.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity. Timepoint: Before intervention, 10 days after beginning of intervention. Method of measurement: Visual analog scale.;Number of acetaminophen administration. Timepoint: 10 days after beginning of intervention. Method of measurement: Empty acetaminophen blister which will be recieved by patients.
- Secondary Outcome Measures
Name Time Method Serum concentration of sodium valproate. Timepoint: 10 days after beginning intervention. Method of measurement: Gas chromatography with flame ionization detector.