PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Active, not recruiting

• Conditions: Acute Ischemic Stroke

• Registration Number: NCT04571177
• Lead Sponsor: University of Alberta

Brief Summary

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Detailed Description

Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

Study Timeline

• Study Start: 2016-02-01
• Study First Submitted: 2020-05-19
• Study First Submitted QC: 2020-09-25
• Study First Posted: 2020-09-30
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-27
• Last Update Posted: 2025-03-28
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age: >18 yo
• Gender: male or female
• Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke

Exclusion Criteria

• 1. Planned surgical intervention
• 2. Severely abnormal blood glucose level (will be excluded from FDG PET imaging)
• 3. Unable to undergo CTP or PET imaging (i.e. claustrophobia)
• 4. Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare PET brain perfusion imaging to CTP	through study completion, 1 year from start of recruitment	Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches.

Trial Locations

Locations (1)

University of Alberta; 🇨🇦 Edmonton, Alberta, Canada