Effects of Lumbar Sympathetic Blockade Renal Plasma Flow and Glomerular Filtration Rate.

Completed

Conditions: effects of nerve blockade on the kidney function
10041543
10038430
10009720

Registration Number: NL-OMON41932

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 3

Inclusion Criteria

- age *18 years
- able to give informed consent
- no recent changes or expected changes in antihypertensive medications or psychopharmaca
- we aim at including at least 50% of the patients with an eGFR < 60ml/min. If the number of patients with eGFRs <60ml/min who are willing to participate in the study is more than patients with eGFR> 60ml/min: the patients with the lowest eGFRs will be selected for inclusion.

Exclusion Criteria

- not willing to be informed about unexpected findings during the study
- neurologic disease
- Lung disease
- pregnancy
- renal replacement therapy (hemo- or peritoneal dialysis)
- iodine allergy
- allergy for shellfish
- not being able to resign from cigarette smoking/ nicotine use in any form, for >20 hours ;PLEASE NOTE: the second GFR and RPF measurements will only be performed in patients with a successful persistent blockade that has been clinically assessed by the pain specialist. In the case of LSB: treatment is regarded as successful upon vasodilatation and in the case of splanchnic blockade relief of pain.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary Objective: to assess the effects of lumbar sympathetic blockade on<br /><br>glomerular filtration rate (GFR) and renal plasma flow (RPF) by studying the<br /><br>differences in measured GFR (in ml/min) and the difference in measured ERPF (in<br /><br>ml/min) before and after lumbar sympathetic blockade or splanchnic blockade in<br /><br>patients with a clinically assessed effective permanent blockade. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary Objective(s):<br /><br>to assess the differences before and after effective lumbar sympathetic<br /><br>blockade or splanchnic blockade in daytime office based blood pressure and<br /><br>systemic haemodynamics (non-invasive estimations of stroke volume, cardiac<br /><br>output, systemic vascular resistance and pulse wave velocity) </p><br>