Effects of Lumbar Sympathetic Blockade Renal Plasma Flow and Glomerular Filtration Rate. - RELIEF study

Academisch Medisch Centrum0 个研究点目标入组 3 人开始时间: 待定最近更新: 2024年4月23日

试验速览

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•- age *18 years
•- able to give informed consent
•- no recent changes or expected changes in antihypertensive medications or psychopharmaca
•- we aim at including at least 50% of the patients with an eGFR < 60ml/min. If the number of patients with eGFRs <60ml/min who are willing to participate in the study is more than patients with eGFR> 60ml/min: the patients with the lowest eGFRs will be selected for inclusion.

•- not willing to be informed about unexpected findings during the study
•- neurologic disease
•- Lung disease
•- pregnancy
•- renal replacement therapy (hemo- or peritoneal dialysis)
•- iodine allergy
•- allergy for shellfish
•- not being able to resign from cigarette smoking/ nicotine use in any form, for >20 hours ;PLEASE NOTE: the second GFR and RPF measurements will only be performed in patients with a successful persistent blockade that has been clinically assessed by the pain specialist. In the case of LSB: treatment is regarded as successful upon vasodilatation and in the case of splanchnic blockade relief of pain.

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