NCT01960309
Unknown
Not Applicable
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardium; Injury
- Sponsor
- UMC Utrecht
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Coronary artery disease
- Last Updated
- 11 years ago
Overview
Brief Summary
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery. The primary objective is to quantify coronary artery disease, as determined by coronary CT and MR, as a cause of postoperative myocardial injury. The secondary objective is to correlate coronary calciumscore to postoperative levels of troponin.
Investigators
Wilton A van Klei
W.A. van Klei, MD PhD
UMC Utrecht
Eligibility Criteria
Inclusion Criteria
- •Major noncardiac surgery with a planned minimal postoperative hospital stay of 2 days
- •Age \> 59 years
- •Troponin_I elevation \> 0.06 ng/ml in the first 3 post-operative days
- •No clinical symptoms of myocardial ischemia
Exclusion Criteria
- •Perioperative troponin elevation due to other factors than coronary artery disease such as proven pulmonary embolism or sepsis
- •Perioperative ST-elevation myocardial infarction (STEMI)
- •Perioperative symptomatic angina with troponin elevation
- •Patients with a history or ECG-signs of myocardial infarction
- •Patients with pre-existent heart failure, left ventricular dysfunction, significant valvular disease or left ventricle hypertrophy
- •Patients with significant valvular disease or left ventricle hypertrophy determined postoperatively with echocardiography.
- •Contra-indication for CMR such as claustrophobia or metal prosthesis
- •Allergic reaction to CT-contrast or gadolinium
- •Renal dysfunction with GFR \< 50 ml/min, as determined after the operation
- •Unstable hemodynamics or other conditions disabling transport to the Radiology department
Outcomes
Primary Outcomes
Coronary artery disease
Time Frame: During hospital admission
Coronary artery disease with luminal narrowing \> 50 % in one or more major epicardial vessels by CCTA.
Secondary Outcomes
- Coronary calcium score(During hospital admission)
- Extent of coronary artery atherosclerosis(During hospital admission)
- Minimal myocardial injury(During hospital admission)
Study Sites (1)
Loading locations...
Similar Trials
Completed
Not Applicable
Minimal invasive imaging of coronary artery disease in patients with asymptomatic myocardial injury after major non-cardiac surgery.Myocardial damageheart attack10011082NL-OMON39130niversitair Medisch Centrum Utrecht70
Unknown
Not Applicable
Less Invasive Detection and Treatment of Very Early Coronary Artery Disease in Patients With Diabetes MellitusType 2 DiabetesMicrovascular DysfunctionNCT00797186University of Virginia150
Completed
Not Applicable
on-invasive Assessment of Coronary Artery Disease in Patients with Chest Pain.Patients with suspected coronary artery diseaseNL-OMON24749100
Completed
Not Applicable
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell TransplantCancer SurvivorDiabetes MellitusHypertensionNCT02077218City of Hope Medical Center20
Not yet recruiting
Not Applicable
Non-invasive Detection of Coronary Artery StenosisCoronary Arterial Disease (CAD)NCT06750016Nilocas20