Minimal invasive imaging of coronary artery disease in patients with asymptomatic myocardial injury after major non-cardiac surgery.
Completed
- Conditions
- Myocardial damageheart attack10011082
- Registration Number
- NL-OMON39130
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
Major non-cardiac surgery with > 2 overnight stay
Troponin elevation post-operatively: > 0.01 ng/ml
Age > 60 year
No clinical signs of myocardial ischemia
Exclusion Criteria
Hemodynamic instability
Contra-indication for MRI e.g.metal prosthesis
Previous myocardial infarction
Severe renal failure: GFR < 30 ml/min
Contrast allergy
AV-block grade 2 or 3.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters:<br /><br><br /><br><br /><br>1. Coronary artery disease with luminal narrowing > 50 % in one or more major<br /><br>epicardial vessels by CT<br /><br>2. Presence and extent of coronary artery atherosclerosis as measured with<br /><br>coronary CT<br /><br>3. Minimal myocardial injury measured by late gadolinium enhancement on MRI<br /><br>4) Myocardial ischemia on adenosin perfuion MRI</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameter:<br /><br><br /><br>Agatston coronary calcium score.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie asymptomatic myocardial injury after non-cardiac surgery in coronary artery disease patients?
How does minimal invasive imaging compare to coronary angiography in detecting CAD post-asymptomatic myocardial injury?
Which biomarkers correlate with silent myocardial damage in patients undergoing major non-cardiac surgery?
What adverse events are associated with minimal invasive cardiac imaging in post-surgical asymptomatic injury cases?
Are there novel imaging agents or techniques targeting atherosclerotic plaques in asymptomatic myocardial injury scenarios?