Multislice computed tomography coronary angiography in patients with stable and unstable angina: a multicentre study
- Conditions
- Angina pectorisCirculatory SystemAngina
- Registration Number
- ISRCTN43894092
- Lead Sponsor
- Erasmus Medical Centre (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 320
Symptomatic patients with stable angina (N = 160) and unstable angina (N = 160) who are scheduled for diagnostic invasive coronary angiography will be enrolled into the study. In addition these patients also need to fulfill the following inclusion criteria:
1. Male and female younger than 70 years
2. Stable angina pectoris that warrants further evaluation by coronary angiography and revascularisation by percutaneous coronary intervention
3. Stable heart rhythm
4. Heart rate less than 70 beats per minute (either spontaneous or drug-induced)
5. No contra-indications such as severe renal or pulmonary dysfunction or X-ray contrast intolerance
1. Older than 70 years, and
2. Have an irregular heart rhythm (predominantly atrial fibrillation), or
3. Have severe renal or pulmonary dysfunction or X-ray contrast intolerance
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic accuracy in terms of sensitivity, specificity and predictive value of MS-CT to detect significant obstructive coronary lesions (more than 50% lumenal diameter reduction with Quantitative Angiography [QCA]) using the diagnostic invasive coronary angiogram as the reference standard. <br><br>The costs, effectiveness, and the cost-effectiveness of non-invasive MS-CT coronary angiography as an initial test will be compared to diagnostic invasive coronary angiography.
- Secondary Outcome Measures
Name Time Method o secondary outcome measures