Rate of Duodenal-biliary Reflux Increases in Patients With Recurrent Common Bile Duct Stones: Direct Evidence From Barium Meal Examination
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Duodenal-biliary reflux rate
研究概览
简要总结
ERCP is the primary choice for removal of common bile duct stone (CBDS) currently. However, 4-24% patients underwent recurrence after successful clearance of CBDS. Stone re-formation due to chronic inflammation of biliary duct is generally considered an important cause of CBDS recurrence, which is associated with duodenal-biliary reflux (DBR) after sphincterotomy. Although it was believed that DBR was the important cause of CBDS recurrence, the direct evidence was still lacking. Here we conducted a case control study to investigate the DBR rate in patients with recurrent CBDS after ERCP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with common bile duct stone underwent successful stone removal by ERCP in Xijing Hospital of Digestive Diseases.
排除标准
- •Gallbladder stones or hepatolithiasis;
- •Stenosis of biliary duct;
- •Incomplete common bile duct stone removal by ERCP;
- •Common bile duct stent;
- •Unable to provide informed consent.
结局指标
主要结局
Duodenal-biliary reflux rate
时间窗: up to 6 months
The proportion of patients with barium reflux into bile duct during the standard barium meal examination.
次要结局
- Distal common bile duct angle(up to 6 months)
- Maximal CBD diameter(up to 6 months)
- Peripapillary diverticulum(up to 6 months)
- Pneumobilia(up to 6 months)
研究者
Yanglin Pan
Associated professor
Air Force Military Medical University, China