The impact of assessing and treating bile acid malabsorption on function and quality of life in patients with major Low Anterior Resection Syndrome (LARS).

Phase 3

• Conditions: ow Anterior Resection; Rectal cancer; Bile Salt Malabsorption; Ultra-low anterior resection; Surgery - Other surgery; High anterior resection; Cancer - Bowel - Back passage (rectum) or large bowel (colon); Colorectal cancer; Low Anterior Resection; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12620000755932
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-07-22
• Last Update Posted: 27 July 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1) Surgery at Dunedin Hospital for rectal cancer between 1999-2015.
2) Surgery includes an anterior resection (High anterior resection, Low anterior resection or ultralow anterior resection).
3) Bowel continuity has been re-established.
4) Major LARS score as determined by a LARS score of 30-42.

Exclusion Criteria

1) Age >85 years
2) Participant too unwell to answer questionnaires (for example is known to have dementia).
3) Patients who have a stoma. This includes those who had an abdominoperineal excision or a Hartmann’s procedure and those who have a loop ileostomy which has not been reversed.
4) Identified allergy to colesevelam.

Study & Design

• Study Type: Interventional
• Study Design: Not specified