Goal Direct Therapy to Prevent Acute Kidney Injury After Cardiac Surgery

University of Sao Paulo0 sites214 target enrollmentApril 2015

ConditionsAcute Kidney Injury

Overview

Phase: N/A
Intervention: Not specified
Conditions: Acute Kidney Injury
Sponsor: University of Sao Paulo
Enrollment: 214
Primary Endpoint: Acute Kidney Injury
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

This is an randomised controlled trial to investigate an strategy based in a protocol in prevention of acute kidney injury after cardiac surgery.

Detailed Description

This is a prospective, randomized controlled trial to assess the influence of use of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the development of the Acute Kidney Injury in the postoperative period of cardiac surgery. Patients undergoing cardiac surgery at the Heart Institute (InCor) - Brazil, will be randomized and in accordance with a list of random numbers, generated by a computer program, will be allocated in one of the groups (GDT or standard).

Registry

clinicaltrials.gov

Start Date

April 2015

End Date

April 2017

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Sao Paulo

Responsible Party

Principal Investigator

Eduesley Santana Santos

RN, Ph.D

University of Sao Paulo

Eligibility Criteria

Inclusion Criteria

•Cardiac surgery with Cardiopulmonary Bypass (CPB); Age greater than 18 years; Chronic kidney disease stages 3 and 4 (GFR less than 60 mL/min and greater than 15 mL/min); Sign the informed consent form.

Exclusion Criteria

•Chronic renal insufficiency (GFR less than 15 mL/min); Heart surgery without CPB; Aortic procedures; Heart transplant or congenital heart disease; Prior use of Intra-Aortic Balloon Pump; Decompensated heart failure; Participation in other research protocol.