TRANS-FOODS: Reducing the risk of developing peanut allergy through the skin by improved understanding, modifying peanut snack production, and adjusting skincare practices.

Not Applicable

Conditions: Peanut allergy and atopic dermatitis
Skin and Connective Tissue Diseases

Registration Number: ISRCTN12492694

Lead Sponsor: King's College London

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Ongoing

Sex: All

Target Recruitment: 120

Inclusion Criteria

1. Adult healthy volunteers (50% of the cohort), and adults with dry skin and AD (fulfilling the refined Hanifin and Rajka criteria, 50% of the cohort).
2. Written informed consent for study participation.
3. Competent use of English language.
4. Willingness to comply with all study requirements.

Exclusion Criteria

1. Patients unable to give informed consent.
2. History of peanut allergy.
3. Positive skin prick test to peanut (>0 mm).
4. No regular consumption of peanut products.
5. Widespread AD, in particular if this involves the test sites of the forearms.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Detection of peanut protein components (µg of the proteins per cm² of skin) in retrieved interstitial fluid. [ Time Frame: 8 weeks ]<br>2. Activation of blood basophil/mast cell from peanut allergic donors (measured as %CD63-positive basophils/mast cells) by peanut proteins present in interstitial fluid. [ Time Frame: 8 weeks ]

Secondary Outcome Measures

Name	Time	Method
1. Detection of inflammatory cytokine markers (IL-4, IL-13, IL-33 and TSLP) in interstitial fluid. [ Time Frame: 8 weeks ]<br>2. Raised transepidermal water loss. [ Time Frame: 8 weeks ]