Feasibility of Protective Ventilation Based on the Alveolar Ventilation in Paediatric Anaesthesiology and Intensive Care.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Determination of target alveolar minute volume to maintain normocapnia in children without mechanical ventilation.
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
Protective ventilation decreased morbidity and mortality in adults' patients and is now a standard of care in intensive care unit and in anesthesiology. In children, there is no evidence in the literature to recommend protective ventilation during anaesthesia. Moreover the ratio of instrumental dead space to tidal volume is higher in children than in adults. Therefore, it is difficult to propose an "optimal" tidal volume for all children. The objective of this study is to evaluate the use of alveolar ventilation (estimated by the volumetric capnography) in children under anesthesia. The hypothesis is that in children, alveolar ventilation reported to ideal body weight is a constant to maintain normocarbia, unlike the tidal volume.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Children aged \< 12 and
- •Weight between 5 and 40kg
- •General anesthesia
- •Non-opposition of parents or legal guardians
Exclusion Criteria
- •History of bronchodysplasia or laryngo tracheo malacia, cyanotic heart disease or neuromuscular disease
- •Airleaks \> 10%
- •Bronchospasm during anesthesia
Outcomes
Primary Outcomes
Determination of target alveolar minute volume to maintain normocapnia in children without mechanical ventilation.
Time Frame: 5 minutes after hemodynamic and ventilatory stabilization period
The minute alveolar ventilation estimated by the volumetric capnography reported to the ideal body weight based on 100 breaths (expressed in ml/Kg/min).