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Clinical Trials/NCT04193254
NCT04193254
Completed
N/A

Relation of Pulmonary Protective Ventilation, Mechanical Power and Driving Pressure With Mortality and SOFA of Mechanically Ventilated Patients in ER, Ward and ICU at General Hospital 11 IMSS Piedras Negras, Coahuila

JOSE IVAN RODRIGUEZ DE MOLINA SERRANO1 site in 1 country63 target enrollmentSeptember 1, 2019

Overview

Phase
N/A
Intervention
Not specified
Conditions
Mechanical Ventilation Complication
Sponsor
JOSE IVAN RODRIGUEZ DE MOLINA SERRANO
Enrollment
63
Locations
1
Primary Endpoint
Correlation of driving pressure with mortality and SOFA
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

Prospective, observational, longitudinal study, September 2019 to March 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila. The investigators aim to assess the relation of lung protective ventilation, mechanical power and driving pressure in mortality and SOFA of mechanically ventilated patients inside and outside ICU at the General Hospital of Zona 11 Piedras Negras, IMSS

Detailed Description

Prospective, observational, longitudinal study from Sept 2019 to Feb 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras Coahuila. Independent variable: Lung protective ventilation, Mechanical power, Driving pressure Dependent variable: Hospital Mortality, Sequential Organic Failure Assessment (SOFA) Also will be registered: 1. Primary diagnosis 2. Compliance with lung protective ventilation 3. Complications associated to mechanical ventilation 4. Quality of attention indicators for MV patients as defined by Semicyuc. 5. Real mortality vs Expected mortality analysis

Registry
clinicaltrials.gov
Start Date
September 1, 2019
End Date
March 1, 2020
Last Updated
6 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
JOSE IVAN RODRIGUEZ DE MOLINA SERRANO
Responsible Party
Sponsor Investigator
Principal Investigator

JOSE IVAN RODRIGUEZ DE MOLINA SERRANO

Head of ICU Jose Ivan RodriguezdeMolina Critical Care Ph.

IMSS Hospital General de Zona 11, Piedras Negras

Eligibility Criteria

Inclusion Criteria

  • Patients with 18 years or older, with invasive mechanical ventilation

Exclusion Criteria

  • Patients with 17 years or younger

Outcomes

Primary Outcomes

Correlation of driving pressure with mortality and SOFA

Time Frame: Sept 19-Feb 20

Driving Pressure: Quantitative variabel, calculated using: Pplateau pressure-PEEP. nomral range \< 13

Correlation of Lung protective ventilation with mortality and SOFA (Sequential Organic Failure Assessment)

Time Frame: Sept 19-Feb 20

Lung Protective Ventilation: Qualitative variable will be defined as YES or NO with the averages of the daily measurements of tidal volume and Pressure plateau. It is defined as Tidal volume (Vc or Vt) \<8 ml / kg (ideal weight) and Plateau or plateau pressure (Ppl, Pm) \<30cmH2O

Correlation of mechanical power with mortality and SOFA

Time Frame: Sept 19-Feb 20

Mechanical power: Quantitative variable. calculated using Marinni equation: MP= (0.098)x(Plateau pressure-PEEP)x Respiratory Rate xTidal Volume. Normal range \< 13

Study Sites (1)

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