A Mindfulness-Based Stress Reduction programme in at-risk mutation carriers of genetic frontotemporal dementia
Completed
- Conditions
- 1002929910012272frontotemporal dementia
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
Asymptomatic, first-degree relatives of FTD patients due to genetic mutations (MAPT, GRN or C9orf72 genes). They have 50% chance of having the mutation and therefore developing FTD. Age of 18 years and over.
Exclusion Criteria
Symptomatic or participants suspect for developing FTD (Clinical Dementia Rating Scale > 0.5).
Persons with a previous or other (neurological) condition (e.g. stroke, brain tumour, MS) that may affect cognitive functioning to such a degree that it hampers study participation.
Current severe psychiatric conditions (e.g. clinical depression or anxiety disorders).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is the total, depression subscore (HADS-D) and<br /><br>anxiety subscore (HADS-A) of the HADS, developed to measure psychological<br /><br>distress in somatic patient populations (Zigmond & Snaith, 1983; Spinhoven et<br /><br>al., 1997; Norton et al., 2013). In short, it consists of a 7-item depression<br /><br>(HADS-D) and a 7-item anxiety (HADS-A) subscale. The HADS has good psychometric<br /><br>qualities in the general medical population (Bjelland et al., 2002). Internal<br /><br>consistency (Cronbach*s *) ranged between 0.84-0.90 (Spinhoven et al., 1997;<br /><br>Bjelland et al., 2002). Test-retest reliability was good (Pearson*s r >0.80)<br /><br>(Spinhoven et al., 1997). </p><br>
- Secondary Outcome Measures
Name Time Method