A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification
- Conditions
- GlioblastomaGliosarcoma
- Interventions
- Registration Number
- NCT02573324
- Lead Sponsor
- AbbVie
- Brief Summary
This study seeks to determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide (TMZ) followed by combination of ABT-414 with adjuvant TMZ prolongs overall survival (OS) among participants with newly diagnosed glioblastoma (GBM) with epidermal growth factor receptor (EGFR) amplification.
In addition, there is a Phase 1, open-label, multicenter sub-study to assess the pharmacokinetics, safety and tolerability of ABT-414 in participants with newly diagnosed EGFR-amplified GBM who have mild or moderate hepatic impairment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 691
- Must have a clinical diagnosis of glioblastoma (GBM).
- Must have a confirmed epidermal growth factor receptor amplification in tumor tissue.
- Must have a Karnofsky Performance Status (KPS) >= 70 at assessment <= 14 days prior to randomization (N/A to the sub-study).
- Must have recovered from effects of surgery, postoperative infection and other complications of surgery.
- Must have adequate bone marrow, renal, and hepatic function (For the sub-study, the participant must have adequate bone marrow and renal function and have mild-to-moderate hepatic impairment).
- Multifocal, recurrent or metastatic GBM or gliomatosis cerebri (For the sub-study, the participant can have multifocal GBM and glimatosis cerebri but can't have recurrent or metastatic GBM).
- Prior chemo therapy or radiosensitizer for head and neck cancer.
- Prior radiotherapy to the head or neck in overlap of radiation fields.
- Prior therapy for glioblastoma or other invasive malignancy.
- Prior, concomitant or planned treatment with Novo Tumor Treatment Fields (Novo-TTF), EGFR-targeted therapy, bevacizumab, Gliadel wafers or other intratumoral or intracavity anti-neoplastic therapy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Open-Label Sub-Study: Depatuxizumab Mafodotin, Radiation and TMZ Temozolomide Depatuxizumab mafodotin is given to participants with hepatic impairment on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Placebo, Radiation and TMZ Radiation Placebo is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Placebo is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Open-Label Sub-Study: Depatuxizumab Mafodotin, Radiation and TMZ Radiation Depatuxizumab mafodotin is given to participants with hepatic impairment on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Depatuxizumab Mafodotin, Radiation and Temozolomide (TMZ) Radiation Depatuxizumab mafodotin is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Placebo, Radiation and TMZ Placebo for ABT-414 Placebo is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Placebo is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Depatuxizumab Mafodotin, Radiation and Temozolomide (TMZ) Temozolomide Depatuxizumab mafodotin is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Placebo, Radiation and TMZ Temozolomide Placebo is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Placebo is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Open-Label Sub-Study: Depatuxizumab Mafodotin, Radiation and TMZ Depatuxizumab mafodotin Depatuxizumab mafodotin is given to participants with hepatic impairment on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase. Depatuxizumab Mafodotin, Radiation and Temozolomide (TMZ) Depatuxizumab mafodotin Depatuxizumab mafodotin is given on Day 1 of Week 1, 3 and 5 along with the standard therapy of TMZ and radiation during the chemoradiation phase. Depatuxizumab mafodotin is given on Day 1 and 15 of each cycle along with TMZ (Days 1-5 of each cycle) per standard of care during the adjuvant phase.
- Primary Outcome Measures
Name Time Method Overall Survival (OS) Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). Time to OS is defined as the number of days from the date of randomization to the date of death due to any cause.
- Secondary Outcome Measures
Name Time Method OS for the MGMT Methylated Group Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). Time to OS is defined as the number of days from the date of randomization to the date of death due to any cause.
OS for the O6-methylguaninemethlytransferese (MGMT) Unmethylated Group Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). Time to OS is defined as the number of days from the date of randomization to the date of death due to any cause.
Unmethylated MGMT promoter is associated with a worse prognosis in GBMOS for the Epidermal Growth Factor Receptor (EGFR)vIII-Mutated Tumor Subgroup Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). Time to OS is defined as the number of days from the date of randomization to the date of death due to any cause.
Progression-Free Survival (PFS) Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). PFS will be defined as the number of days from the date of randomization to the date of earliest disease progression based on Response Assessment in Neuro-Oncology (RANO) criteria (see Wen et al. J Clin Oncol. 2010 Apr 10;28(11):1963-72) or to the date of death, if disease progression does not occur.
PFS for EGFRvIII-Mutated Tumor Subgroup Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). PFS will be defined as the number of days from the date of randomization to the date of earliest disease progression based on Response Assessment in Neuro-Oncology (RANO) criteria or to the date of death, if disease progression does not occur.
Deterioration Free Survival in M.D. Anderson Symptom Inventory Brain Tumor Module (MDASI-BT) Symptom Severity Score Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). The MDASI-BT assesses the severity of multiple brain tumor-related symptoms and the impact of these symptoms on daily functioning in the last 24 hours. It consists of 22 symptom items and 6 interference items, each rated from 0 to 10. MDASI-BT symptom severity score is defined as average over 13 core symptom items and 9 brain tumor symptom items, with a total score of 0 to 10, with higher score indicating worse symptoms/interference. Changes in symptom severity score were classified into 3 categories: improved (≤ -1), stable (\> -1 and \< 1), and deteriorated (≥ 1). Deterioration is defined as satisfying the deterioration criteria (i.e., increase in symptom severity score by ≥ 1 unit) without further improvement (i.e., failing to satisfy deterioration criteria) within 8 weeks or occurrence of death.
Deterioration Free Survival in MDASI-BT Symptom Interference Score Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). The MDASI-BT assesses the severity of multiple brain tumor-related symptoms and the impact of these symptoms on daily functioning in the last 24 hours. It consists of 22 symptom items and 6 interference items, each rated from 0 to 10. MDASI-BT symptom interference score is defined as an average of 6 interference items, with a total score of 0 to 10, where higher scores indicate worse interference. Changes in symptom interference score were classified into 3 categories: improved (≤ -1), stable (\> -1 and \< 1), and deteriorated (≥ 1). Deterioration is defined as satisfying the deterioration criteria (i.e., increase in symptom interference score by ≥ 1 unit) without further improvement (i.e., failing to satisfy deterioration criteria) within 8 weeks or occurrence of death.
Deterioration Free Survival in Neurocognitive Functioning on the Hopkins Verbal Learning Test Revised (HVLT-R) Total Recall Score Overall median duration of follow-up was 15.5 months (range: 0.1, 35.6). The HVLT-R consists of 3 parts. Free call has a range of 0 to 36, delayed recall has a range from 0 to 12, and delayed recognition has a range of -12 to 12. Higher scores indicating better function in all 3 parts. When scoring the HVLT-R, the 3 learning trials are combined to calculate a total recall score (range -12 to 60). Deterioration is defined as satisfying the deterioration criteria (i.e., decrease in HVLT-R total recall score by 5 units) without further improvement within 8 weeks or occurrence of death.
Trial Locations
- Locations (212)
Piedmont Hospital /ID# 145892
🇺🇸Atlanta, Georgia, United States
Emory Midtown Infectious Disease Clinic /ID# 144015
🇺🇸Atlanta, Georgia, United States
University of Pennsylvania Medical Center - Shadyside /ID# 144159
🇺🇸Pittsburgh, Pennsylvania, United States
Allegheny General Hospital /ID# 144126
🇺🇸Pittsburgh, Pennsylvania, United States
Princess Margaret Cancer Centre /ID# 166277
🇨🇦Toronto, Ontario, Canada
Northwestern Medicine Cancer Center - Warrenville /ID# 148476
🇺🇸Warrenville, Illinois, United States
Thomas Jefferson University /ID# 144191
🇺🇸Philadelphia, Pennsylvania, United States
Baylor Sammons Cancer Center /ID# 155542
🇺🇸Dallas, Texas, United States
Liverpool Hospital /ID# 144392
🇦🇺Liverpool, New South Wales, Australia
Tufts Medical Center /ID# 145897
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital /ID# 144145
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute /ID# 148475
🇺🇸Boston, Massachusetts, United States
Cleveland Clinic Main Campus /ID# 144023
🇺🇸Cleveland, Ohio, United States
Duplicate_Univ Hosp Cleveland /ID# 144153
🇺🇸Cleveland, Ohio, United States
The University of Texas Health Science Center at Houston /ID# 144013
🇺🇸Houston, Texas, United States
University of Texas MD Anderson Cancer Center /ID# 144018
🇺🇸Houston, Texas, United States
Virginia Mason Medical Center /ID# 144022
🇺🇸Seattle, Washington, United States
Christiana Care Health Service /ID# 144127
🇺🇸Newark, Delaware, United States
Highlands Oncology Group, PA /ID# 142050
🇺🇸Springdale, Arkansas, United States
Associated Neurologists of Sou /ID# 147701
🇺🇸Fairfield, Connecticut, United States
Maine Medical Partners Neurolo /ID# 160864
🇺🇸Scarborough, Maine, United States
Duplicate_Instituto Med Alex Flem /ID# 142884
🇦🇷Buenos Aires, Argentina
Sanatorio Parque /ID# 142825
🇦🇷Rosario, Santa Fe, Argentina
Medizinische Universitaet Wien /ID# 141981
🇦🇹Vienna, Wien, Austria
St Vincent's Hospital Melbourne /ID# 143858
🇦🇺Fitzroy Melbourne, Victoria, Australia
Duplicate_Austin Hospital /ID# 143859
🇦🇺Heidelberg, Victoria, Australia
Royal Victoria Hospital / McGill University Health Centre /ID# 144187
🇨🇦Montreal, Quebec, Canada
Medizinische Universitaet Graz /ID# 141982
🇦🇹Graz, Steiermark, Austria
Duplicate_Medizinische Universitat Innsbruck,Universitatsklinik fur Innere Mediz /ID# 141984
🇦🇹Innsbruck, Austria
UZ Gent /ID# 141647
🇧🇪Gent, Oost-Vlaanderen, Belgium
Kepler Universitätsklinikum GmbH - Neuromed Campus /ID# 141983
🇦🇹Linz, Austria
UCL Saint-Luc /ID# 141648
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Universitair Ziekenhuis Leuven /ID# 143872
🇧🇪Leuven, Vlaams-Brabant, Belgium
Grand Hopital de Charleroi /ID# 141645
🇧🇪Charleroi, Hainaut, Belgium
Duplicate_Centre Hospitalier Jolimont /ID# 143873
🇧🇪La Louvière, Belgium
Centro Medico Imbanaco de Cali /ID# 143882
🇨🇴Cali, Colombia
IPO Lisboa FG, EPE /ID# 141938
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 141941
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 142830
🇵🇹Porto, Portugal
Regional Clinical Hospital of Kaliningrad region /ID# 141702
🇷🇺Kaliningrad, Kaliningradskaya Oblast, Russian Federation
GEMC - European Medical Center /ID# 141703
🇷🇺Moscow, Moskovskaya Oblast, Russian Federation
National Medical Research Center for Neurosurgery n.a. N. N. Burdenko /ID# 141701
🇷🇺Moscow, Moskva, Russian Federation
Federal State Budgetary Scientific Institution N.N. Blokhin /ID# 141707
🇷🇺Moscow, Moskva, Russian Federation
Federal State Treatment and Rehabilitation center /ID# 141704
🇷🇺Moscow, Moskva, Russian Federation
University of Free State, Universitas Annex (National Hospital Grounds) /ID# 144064
🇿🇦Bloemfontein, Free State, South Africa
Sverdlovsk Regional Oncology Dispensary /ID# 141700
🇷🇺Yekaterinburg, Sverdlovskaya Oblast, Russian Federation
Cape Town Oncology Trials /ID# 143948
🇿🇦Kraaifontein, Western Cape, South Africa
Vrije Universiteit Medisch Centrum /ID# 143889
🇳🇱Amsterdam, Netherlands
Beaumont Hospital /ID# 142969
🇮🇪Beaumont, Dublin, Ireland
Univ Kansas Cancer Ctr - Overl /ID# 145895
🇺🇸Westwood, Kansas, United States
Sharp Memorial Hospital /ID# 148193
🇺🇸San Diego, California, United States
Univ California, San Francisco /ID# 145889
🇺🇸San Francisco, California, United States
Baptist Hospital Miami /ID# 152451
🇺🇸Miami, Florida, United States
University of Utah /ID# 144160
🇺🇸Salt Lake City, Utah, United States
St. Josephs Hospital and Med Center /ID# 144149
🇺🇸Phoenix, Arizona, United States
Wayne State University /ID# 145890
🇺🇸Detroit, Michigan, United States
Henry Ford Health System /ID# 145896
🇺🇸Detroit, Michigan, United States
Univ Oklahoma HSC /ID# 144161
🇺🇸Oklahoma City, Oklahoma, United States
Moffitt Cancer Center /ID# 144130
🇺🇸Tampa, Florida, United States
Nebraska Methodist Hospital /ID# 144140
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center /ID# 145899
🇺🇸Omaha, Nebraska, United States
Froedtert Memorial Lutheran Hospital /ID# 144139
🇺🇸Milwaukee, Wisconsin, United States
University of Southern California /ID# 147543
🇺🇸Los Angeles, California, United States
University of California, Los Angeles /ID# 149239
🇺🇸Los Angeles, California, United States
Duplicate_St. John's Health Center /ID# 148192
🇺🇸Santa Monica, California, United States
Cedars-Sinai Medical Center-West Hollywood /ID# 148472
🇺🇸West Hollywood, California, United States
Univ of Colorado Cancer Center /ID# 148194
🇺🇸Aurora, Colorado, United States
Holy Cross Hospital /ID# 156764
🇺🇸Fort Lauderdale, Florida, United States
Boca Raton Regional Hospital /ID# 163659
🇺🇸Boca Raton, Florida, United States
Northwestern University Feinberg School of Medicine /ID# 147895
🇺🇸Chicago, Illinois, United States
The University of Chicago Medical Center /ID# 144158
🇺🇸Chicago, Illinois, United States
Parkview Research Ctr, Hosp /ID# 144150
🇺🇸Fort Wayne, Indiana, United States
Duplicate_St. Joseph Mercy Hospital /ID# 144143
🇺🇸Ypsilanti, Michigan, United States
Mmcorc /Id# 144146
🇺🇸Saint Louis Park, Minnesota, United States
Washington University-School of Medicine /ID# 144174
🇺🇸Saint Louis, Missouri, United States
Columbia University Medical Center /ID# 144020
🇺🇸New York, New York, United States
MD Anderson Cancer Center at Cooper - Camden /ID# 145891
🇺🇸Camden, New Jersey, United States
Rutgers Cancer Institute of New Jersey /ID# 148190
🇺🇸New Brunswick, New Jersey, United States
University of Rochester Medical Center /ID# 144166
🇺🇸Rochester, New York, United States
University of Cincinnati /ID# 144164
🇺🇸Cincinnati, Ohio, United States
Levine Cancer Ins, Carolina Me /ID# 144124
🇺🇸Charlotte, North Carolina, United States
The Ohio State University /ID# 144016
🇺🇸Columbus, Ohio, United States
University of Toledo /ID# 156763
🇺🇸Toledo, Ohio, United States
St. Luke's Hospital /ID# 148191
🇺🇸Bethlehem, Pennsylvania, United States
Fox Chase Cancer Center /ID# 145893
🇺🇸Philadelphia, Pennsylvania, United States
University of Pennsylvania /ID# 157623
🇺🇸Philadelphia, Pennsylvania, United States
Austin Cancer Centers /ID# 151061
🇺🇸Austin, Texas, United States
Duplicate_Scott and White Medical Center /ID# 160743
🇺🇸Temple, Texas, United States
Intermountain Medical Center /ID# 144142
🇺🇸Murray, Utah, United States
University of Washington /ID# 144162
🇺🇸Seattle, Washington, United States
Inova Health System /ID# 152956
🇺🇸Falls Church, Virginia, United States
Univ of Wisconsin Hosp/Clinics /ID# 144167
🇺🇸Madison, Wisconsin, United States
Duplicate_The Prince of Wales Hospital /ID# 144882
🇦🇺Randwick, New South Wales, Australia
Calvary Mater Newcastle /ID# 143860
🇦🇺Waratah, New South Wales, Australia
Southern Medical Day Care Centre /ID# 143868
🇦🇺Wollongong, New South Wales, Australia
Royal North Shore Hospital /ID# 143870
🇦🇺St Leonards, New South Wales, Australia
Princess Alexandra Hospital /ID# 143857
🇦🇺Woolloongabba, Queensland, Australia
Calvary North Adelaide Hospita /ID# 143866
🇦🇺Adelaide, South Australia, Australia
St John Of God Subiaco Hospital /ID# 143869
🇦🇺Subiaco, Western Australia, Australia
Liga Norte Riograndense Contra o Câncer /ID# 143878
🇧🇷Natal, Rio Grande Do Norte, Brazil
Duplicate_UCL Mont Godinne /ID# 141644
🇧🇪Yvoir, Belgium
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) /ID# 143877
🇧🇷Rio de Janeiro, Brazil
CHU de Liege /ID# 162860
🇧🇪Liege, Belgium
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 143876
🇧🇷Barretos, Sao Paulo, Brazil
Hospital Sao Lucas da PUCRS /ID# 143879
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Juravinski Cancer Centre /ID# 152117
🇨🇦Hamilton, Ontario, Canada
Instituto do Câncer do Estado de São Paulo - ICESP /ID# 144031
🇧🇷São Paulo, Sao Paulo, Brazil
Victoria Hospital /ID# 144184
🇨🇦London, Ontario, Canada
Duplicate_Hospital Maisonneuve-Rosemont /ID# 149315
🇨🇦Montreal, Quebec, Canada
Duplicate_Jewish General Hospital /ID# 144029
🇨🇦Montreal, Quebec, Canada
Ottawa Hospital Research Institute /ID# 150120
🇨🇦Ottawa, Ontario, Canada
CHUM - Notre-Dame Hospital /ID# 144027
🇨🇦Montréal, Quebec, Canada
CHU de Quebec-Universite Laval /ID# 144189
🇨🇦Quebec City, Quebec, Canada
CHUS - Hopital Fleurimont /ID# 149771
🇨🇦Sherbrooke, Quebec, Canada
Anhui Provincial Hospital /ID# 166320
🇨🇳Hefei, Anhui, China
Duplicate_Xiangya Hospital Central South University /ID# 166791
🇨🇳Changsha, Hunan, China
SanboBrain Hospital Capital Medical University /ID# 166422
🇨🇳Beijing, Beijing, China
Tongji Hospital Tongji Medical College of HUST /ID# 163820
🇨🇳Wuhan, Hubei, China
Sun Yat-Sen University Cancer Center /ID# 143919
🇨🇳Guangzhou, Guangdong, China
The First Affiliated Hospital of Soochow University /ID# 165596
🇨🇳Suzhou, Jiangsu, China
Peking Union Medical College Hospital /ID# 157430
🇨🇳Beijing, Beijing, China
Duplicate_Tangdu Hospital /ID# 143920
🇨🇳Xi'an, Shaanxi, China
The First Affiliated Hospital of Fujian Medical University /ID# 159166
🇨🇳Fuzhou, China
Duplicate_The Second Affiliated Hospital of ZUSM /ID# 165593
🇨🇳Hangzhou, Zhejiang, China
Beijing Tian Tan Hospital, Capital Medical University /ID# 167160
🇨🇳Beijing, China
Duplicate_Huashan Hospital of Fudan University /ID# 159999
🇨🇳Shanghai, Shanghai, China
Duplicate_Shengjing Hospital of China Medical University /ID# 167016
🇨🇳Shenyang, China
Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 147223
🇨🇴Monteria, Cordoba, Colombia
Administradora del Country_S.A-Clinica Del Country /ID# 143881
🇨🇴Bogota, Cundinamarca, Colombia
Duplicate_Tianjin Med Univ General Hosp /ID# 143923
🇨🇳Tianjin, China
Oncologos del Occidente S.A /ID# 147713
🇨🇴Pereira, Risaralda, Colombia
Duplicate_FN Hradec Kralove /ID# 143885
🇨🇿Hradec Kralove, Czechia
Masarykuv onkologicky ustav /ID# 143884
🇨🇿Brno, Czechia
Hospital Pablo Tobon Uribe /ID# 143780
🇨🇴Medellín, Antioquia, Colombia
Krajska nemocnice Liberec, a.s. /ID# 142024
🇨🇿Liberec, Czechia
AP-HM - Hopital de la Timone /ID# 143911
🇫🇷Marseille CEDEX 05, Bouches-du-Rhone, France
Hopital Avicenne - APHP /ID# 143910
🇫🇷Bobigny, Ile-de-France, France
Fakultni Nemocnice v Motole /ID# 142023
🇨🇿Praha, Czechia
Duplicate_Gustave Roussy /ID# 143912
🇫🇷Villejuif Cedex, Ile-de-France, France
Duplicate_Univ Hosp Ostrava-Poruba /ID# 143883
🇨🇿Ostrava, Czechia
CHRU Lille - Hopital Claude Huriez /ID# 143915
🇫🇷Lille, Hauts-de-France, France
Insititut de Cancerologie /ID# 143908
🇫🇷Angers, France
Institut de Cancérologie de l'Ouest René Gauducheau /ID# 143914
🇫🇷St Herblain CEDEX, Loire-Atlantique, France
Hopital Pitie Salpetriere /ID# 143917
🇫🇷Paris, France
CHU Nice -Hopital Pasteur /ID# 143916
🇫🇷Nice CEDEX 1, Provence-Alpes-Cote-d Azur, France
Universitaetsklinikum Tuebingen /ID# 143926
🇩🇪Tubingen, Baden-Wuerttemberg, Germany
Universitaetsklinik Heidelberg /ID# 143927
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH /ID# 143961
🇩🇪Bochum, Germany
Universitaetsklinikum Leipzig /ID# 143962
🇩🇪Leipzig, Sachsen, Germany
Prince of Wales Hospital /ID# 143952
🇭🇰Hong Kong, Hong Kong
The Chaim Sheba Medical Center /ID# 143960
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 143956
🇮🇱Tel Aviv-Yafo, Tel-Aviv, Israel
Rambam Health Care Campus /ID# 143959
🇮🇱Haifa, Israel
Gastroenterology Institute, Division of Medicine /ID# 143958
🇮🇱Jerusalem, Israel
Rabin Medical Center /ID# 143957
🇮🇱Petakh Tikva, Israel
Duplicate_Duplicate_AOU Citta della Salute Scienza /ID# 141801
🇮🇹Turin, Piemonte, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 141800
🇮🇹Milan, Italy
Duplicate_Regina Elena National Cancer I /ID# 141795
🇮🇹Rome, Italy
National Cancer Center /ID# 141845
🇰🇷Goyang, Gyeonggido, Korea, Republic of
Istituto Oncologico Veneto /ID# 143821
🇮🇹Padova, Italy
Duplicate_Yonsei University Health System, Severance hospital. /ID# 141846
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Centro Medico Zambrano Hellion /ID# 143845
🇲🇽San Pedro Garza Garcia, Nuevo Leon, Mexico
Universitair Medisch Centrum Groningen /ID# 141408
🇳🇱Groningen, Netherlands
Universitair Medisch Centrum Utrecht /ID# 141406
🇳🇱Utrecht, Netherlands
Haaglanden Medisch Centrum /ID# 141405
🇳🇱Den Haag, Netherlands
Maastricht Universitair Medisch Centrum /ID# 143585
🇳🇱Maastricht, Netherlands
Duplicate_Canterbury District Health Boa /ID# 143861
🇳🇿Christchurch, New Zealand
Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 143890
🇳🇿Wellington, New Zealand
CCA Braga - Hospital de Braga /ID# 141940
🇵🇹Braga, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 141939
🇵🇹Faro, Portugal
State budgetary healthcare institution Republican Clinical Oncology Dispensary /ID# 141706
🇷🇺Ufa, Kirovskaya Oblast, Russian Federation
National University Hospital /ID# 143933
🇸🇬Singapore, Singapore
National Cancer Ctr Singapore /ID# 143932
🇸🇬Singapore, Singapore
Netcare Unitas Hospital /ID# 152936
🇿🇦Centurion, Gauteng, South Africa
Netcare Oncology Intervent Ctr /ID# 143951
🇿🇦Cape Town, Western Cape, South Africa
The Oncology Centre /ID# 143950
🇿🇦Durban, Kwazulu-Natal, South Africa
Hospital Regional de Malaga /ID# 143902
🇪🇸Málaga, Malaga, Spain
Hospital Clinic de Barcelona /ID# 143906
🇪🇸Barcelona, Spain
Hospital Santa Creu i Sant Pau /ID# 143900
🇪🇸Barcelona, Spain
Hospital Universitario 12 de Octubre /ID# 143930
🇪🇸Madrid, Spain
Hospital Clinico Universitario San Carlos /ID# 143901
🇪🇸Madrid, Spain
Hospital General Universitario de Valencia /ID# 143903
🇪🇸Valencia, Spain
Linkou Chang Gung Memorial Hospital /ID# 143941
🇨🇳Taoyuan City, Taiwan
Kantonsspital Aarau AG /ID# 141885
🇨🇭Aarau, Aargau, Switzerland
Universitatsspital Zurich /ID# 141887
🇨🇭Zurich, Zuerich, Switzerland
Inselspital, Universitätsspital Bern /ID# 141886
🇨🇭Bern, Switzerland
National Taiwan University Hospital /ID# 143940
🇨🇳Taipei City, Taiwan
Duplicate_EOC Ospedale Regionale di Bellinzona e Valli /ID# 143936
🇨🇭Bellinzona, Switzerland
Taipei Veterans General Hosp /ID# 143955
🇨🇳Taipei City, Taiwan
Velindre University NHS Trust /ID# 141996
🇬🇧Cardiff, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 154592
🇬🇧Birmingham, United Kingdom
Guys and St Thomas NHS Foundation Trust /ID# 142652
🇬🇧London, London, City Of, United Kingdom
Leeds Teaching Hospitals NHS Trust /ID# 141653
🇬🇧Leeds, United Kingdom
Duplicate_NHS Tayside /ID# 141651
🇬🇧Dundee, United Kingdom
NHS Lothian /ID# 141802
🇬🇧Edinburgh, United Kingdom
University College London Hospitals NHS Foundation Trust /ID# 142658
🇬🇧London, United Kingdom
Duplicate_The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 141999
🇬🇧Newcastle Upon Tyne, United Kingdom
Royal Marsden Hospital /ID# 142827
🇬🇧Sutton, United Kingdom
Seoul National University Hospital /ID# 143886
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center /ID# 143887
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 141844
🇰🇷Seoul, Korea, Republic of
Hospital Universitario HM Sanchinarro /ID# 143496
🇪🇸Madrid, Spain
Rondebosch Oncology Center /ID# 143949
🇿🇦Cape Town, Western Cape, South Africa
Duplicate_Cancer Care Manitoba /ID# 149253
🇨🇦Winnipeg, Manitoba, Canada
QE II Health Sciences Centre /ID# 151600
🇨🇦Halifax, Nova Scotia, Canada
NorthShore University HealthSystem /ID# 144017
🇺🇸Evanston, Illinois, United States
Royal Adelaide Hospital /ID# 143867
🇦🇺Adelaide, South Australia, Australia
Penn State University and Milton S. Hershey Medical Center /ID# 147525
🇺🇸Hershey, Pennsylvania, United States
Yale University /ID# 144170
🇺🇸New Haven, Connecticut, United States
Advent Health /ID# 144128
🇺🇸Orlando, Florida, United States
Medical University of South Carolina /ID# 144141
🇺🇸Charleston, South Carolina, United States
Virginia Commonwealth University Medical Center Main Hospital /ID# 149014
🇺🇸Richmond, Virginia, United States