The Cognitive and Cardiovascular Health in the Elderly Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Incident "MCI" according to the following criteria
研究概览
简要总结
The main objective of this study is to look for the interest forecast of the IPS as infra-clinical cardiovascular marker in the prediction of a change of the cognitive functions (MCI) at the elderly of 70 and more years old without clinical cardiovascular pathology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •free-living community-dwelling men and women aged ≥ 70 years,
- •subjects free of clinical CVD related to atherosclerosis
- •preserved basic activities of daily living (ADL = 6)
- •without cognitive impairment (MMSE≥24)
排除标准
- •subjects with clinical history of any of the following CVD diseases : coronary artery disease (angina, myocardial infarction, coronary revascularization), cerebrovascular disease (stroke, TIA, carotid revascularization), clinical peripheral artery disease (claudication, critical limb ischemia)
- •subjects with neurodegenerative, locomotor and ophtalmological diseases unable to perform the cognitive tests
- •subjects unable to give written informed consent.
研究组 & 干预措施
Cardiovascular evaluation
Measure of the index of systolic pressure Echo doppler Echography Measure of the speed of the wave of pulse and the central pressure
干预措施: Cardiovascular evaluation (Other)
结局指标
主要结局
Incident "MCI" according to the following criteria
时间窗: one time point
(1) cognitive complaint (self-reported and/or informant) ; (2) preserved basic activities of daily living (ADL) ; (3) cognitive impairment (not normal for age and education) or decline in cognition evidenced by performance on objective cognitive tasks defined as a test performance \<1.0 standard deviations below the mean of the reference group ; (4) preserved general cognitive functioning and (5) absence of dementia.
次要结局
未报告次要终点