Coronary Arterial Microcirculation and Metabolism
- Conditions
- Coronary Atherosclerosis of Native Coronary Artery
- Registration Number
- NCT07074847
- Lead Sponsor
- Shaanxi Provincial People's Hospital
- Brief Summary
Coronary microcirculation disorder refers to a disease in which small blood vessels in the coronary arteries are damaged or blocked, leading to myocardial ischemia and hypoxia. This disease usually occurs in patients with coronary heart disease, but it can also occur in other populations. It is caused by abnormal endothelial function of coronary arteries or spasm of small arteries. Its symptoms include chest pain, shortness of breath, palpitations, etc., which usually occur during physical activity or emotional excitement. If left untreated, it may lead to serious consequences such as myocardial infarction.
The methods for treating coronary microcirculation disorders include drug therapy, surgical treatment, and lifestyle changes. Drug therapy includes antiplatelet drugs, lipid-lowering drugs, vasodilators, etc; Surgical treatment includes coronary artery bypass grafting and percutaneous coronary intervention. Lifestyle changes include quitting smoking, weight control, and increasing physical activity. In summary, coronary microcirculation disorders are a disease that leads to myocardial ischemia and require sufficient attention. Early detection and effective treatment measures can prevent the occurrence of complications and improve the quality of life.
If patients with coronary microcirculation disorders can be detected early and treated accordingly, serious consequences can be avoided. Therefore, we plan to investigate the correlation between coronary microcirculation and metabolomics, with the aim of identifying metabolites closely related to coronary microcirculation from the perspective of metabolomics, in order to elucidate the metabolic processes involved in coronary microcirculation disorders.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 100
- Patients with normal coronary angiography or stenosis less than 50%
- Coronary angiography indicates patients with coronary stenosis greater than 50%.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Microcirculatory resistance index 2025.2.28-2025.12.31
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Cardiology, Shaanxi Provincial People's Hospital
🇨🇳Xi'an, Shaanxi, China
Department of Cardiology, Shaanxi Provincial People's Hospital🇨🇳Xi'an, Shaanxi, China