Neural Mechanisms of Stress Effects Across Hippocampal Encoding and Prediction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 2
- 主要终点
- Changes in fMRI Signal
研究概览
简要总结
The purpose of this study is to investigate the neural mechanisms by which acute stress influences statistical learning and episodic encoding.
详细描述
This study aims to assess the neural and behavioral mechanisms by which acute stress modulates episodic encoding (which involves the trisynaptic pathway: entorhinal cortex, dentate gyrus, cornu ammonis [CA] 3, and CA 1) and statistical learning (monosynaptic pathway: entorhinal cortex, CA1) in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-45 years old
- •Fluent in English
- •BMI 18-35
排除标准
- •Meeting current DSM-V criteria for any substance use disorder (except caffeine)
- •Having current significant medical conditions or psychiatric symptoms requiring medication
- •Current use of medications/drugs that interfere with physiological stress responses
- •Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies
- •Metal in body (for MRI safety) history will be assessed for female participants.
结局指标
主要结局
Changes in fMRI Signal
时间窗: 1-2 hours
fMRI signal during learning will be assessed using connectivity, multivariate, and univariate approaches over 1-2 hour long learning period. Correlation between change in CA1-EC background connectivity and pair familiarity. rho represents the true correlation within the entire population, with values ranging from -1 to +1; values closer to +1 indicate a strong positive linear relationship, closer to -1 a strong negative one, and closer to 0 indicate no linear relationship.
Statistical Learning
时间窗: 1-2 hours
Online measures of statistical learning ( mean reaction time) based on item predictability during task for condition A, B or x.
Retention of Statistical Learning
时间窗: 1 hour
Offline measure of statistical learning assessed through familiarity tests the next day (comparison of accurate recognition of previously-studied pairs to chance, 50%)
Episodic Memory
时间窗: 1 hour
Memory for individual items will be assessed through performance on old/new recognition tests the next day, quantified as hit rates and A' (non-parametric normalized ratio of hits to false alarms). Data presented here is the proportion of studied items attributed to the correct condition (A, B or X) minus the proportion of nonstudied items incorrectly attributed to that same condition.
次要结局
- Cortisol Reactivity(1-2 hours)
- Alpha-amylase Reactivity(1-2 hours)