NCT03614481招募中不适用
Clinical and Genetic Analyzes of Age-related Macular Degeneration
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 6,000
- 试验地点
- 5
- 主要终点
- Genotypic factors
研究概览
简要总结
The purpose of this collection is to search for susceptibility genes for age-related macular degeneration (AMD) alone or in combination with environmental factors and to look for genes that modulate the AMD phenotype (particularly the response to treatment).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age> 55 years
- •Diagnosis of exudative or atrophic AMD in at least one eye
- •Patient informed of the objectives of the study and having freely signed the informed consent letter
- •Patient affiliated to a social security scheme
排除标准
- •Other retinal or choroidal lesion in the studied eye
- •History of severe systemic disease that could potentially hinder patient adherence to the study protocol: mental disorder, cancer, recent stroke or heart failure less than 3 months old.
- •Known allergy to fluorescein, indocyanine green, iodine or ranibizumab
结局指标
主要结局
Genotypic factors
时间窗: 6 months
Identification of genotypic factors associated with good or poor response to treatment in precisely phenotyped AMD patients.
次要结局
- Environmental factors(6 months)
- Circulating biological factors(6 months)
- Predictive markers(6 months)
- Predictive treatment response score(6 months)
- Vascular Endothelial Growth Factor(6 months)
研究者
研究点 (5)
Loading locations...
相似试验
已完成
不适用
Genetic Study of Age-Related Macular DegenerationAge-Related Macular DegenerationNCT00357578National Eye Institute (NEI)150
尚未招募
不适用
Genetic background of age-related macular degeneration in the North-Limburg regio10042261age-related macular degenerationNL-OMON29903niversitair Medisch Centrum Sint Radboud200
已完成
不适用
Research on age-related macular degeneration and diabetic complications using non-invasive AGEs measurement equipment.age-related macular degeneration, diabetic retinopathyJPRN-UMIN000010741Shinshu University Graduate School of Medicine, Department of Ophthalmology500
Unknown
不适用
Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) TherapyWet AMDNCT01310686West Coast Retina Medical Group, Inc.40
Unknown
不适用
The Pathogenesis of Human Senile CataractCataractNCT03907358Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine20