Skip to main content
Clinical Trials/NCT03614481
NCT03614481
Recruiting
Not Applicable

Clinical and Genetic Analyzes of Age-related Macular Degeneration

Centre Hospitalier Intercommunal Creteil5 sites in 1 country6,000 target enrollmentNovember 2005

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Macular Degeneration
Sponsor
Centre Hospitalier Intercommunal Creteil
Enrollment
6000
Locations
5
Primary Endpoint
Genotypic factors
Status
Recruiting
Last Updated
2 years ago

Overview

Brief Summary

The purpose of this collection is to search for susceptibility genes for age-related macular degeneration (AMD) alone or in combination with environmental factors and to look for genes that modulate the AMD phenotype (particularly the response to treatment).

Registry
clinicaltrials.gov
Start Date
November 2005
End Date
November 2024
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age\> 55 years
  • Diagnosis of exudative or atrophic AMD in at least one eye
  • Patient informed of the objectives of the study and having freely signed the informed consent letter
  • Patient affiliated to a social security scheme

Exclusion Criteria

  • Other retinal or choroidal lesion in the studied eye
  • History of severe systemic disease that could potentially hinder patient adherence to the study protocol: mental disorder, cancer, recent stroke or heart failure less than 3 months old.
  • Known allergy to fluorescein, indocyanine green, iodine or ranibizumab

Outcomes

Primary Outcomes

Genotypic factors

Time Frame: 6 months

Identification of genotypic factors associated with good or poor response to treatment in precisely phenotyped AMD patients.

Secondary Outcomes

  • Environmental factors(6 months)
  • Circulating biological factors(6 months)
  • Predictive markers(6 months)
  • Predictive treatment response score(6 months)
  • Vascular Endothelial Growth Factor(6 months)

Study Sites (5)

Loading locations...

Similar Trials