NCT03614481
Recruiting
Not Applicable
Clinical and Genetic Analyzes of Age-related Macular Degeneration
ConditionsMacular Degeneration
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Macular Degeneration
- Sponsor
- Centre Hospitalier Intercommunal Creteil
- Enrollment
- 6000
- Locations
- 5
- Primary Endpoint
- Genotypic factors
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this collection is to search for susceptibility genes for age-related macular degeneration (AMD) alone or in combination with environmental factors and to look for genes that modulate the AMD phenotype (particularly the response to treatment).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age\> 55 years
- •Diagnosis of exudative or atrophic AMD in at least one eye
- •Patient informed of the objectives of the study and having freely signed the informed consent letter
- •Patient affiliated to a social security scheme
Exclusion Criteria
- •Other retinal or choroidal lesion in the studied eye
- •History of severe systemic disease that could potentially hinder patient adherence to the study protocol: mental disorder, cancer, recent stroke or heart failure less than 3 months old.
- •Known allergy to fluorescein, indocyanine green, iodine or ranibizumab
Outcomes
Primary Outcomes
Genotypic factors
Time Frame: 6 months
Identification of genotypic factors associated with good or poor response to treatment in precisely phenotyped AMD patients.
Secondary Outcomes
- Environmental factors(6 months)
- Circulating biological factors(6 months)
- Predictive markers(6 months)
- Predictive treatment response score(6 months)
- Vascular Endothelial Growth Factor(6 months)
Study Sites (5)
Loading locations...
Similar Trials
Completed
Not Applicable
Genetic Study of Age-Related Macular DegenerationAge-Related Macular DegenerationNCT00357578National Eye Institute (NEI)150
Not yet recruiting
Not Applicable
Genetic background of age-related macular degeneration in the North-Limburg regioage-related macular degeneration10042261NL-OMON29903niversitair Medisch Centrum Sint Radboud200
Completed
Not Applicable
Research on age-related macular degeneration and diabetic complications using non-invasive AGEs measurement equipment.age-related macular degeneration, diabetic retinopathyJPRN-UMIN000010741Shinshu University Graduate School of Medicine, Department of Ophthalmology500
Unknown
Not Applicable
Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) TherapyWet AMDNCT01310686West Coast Retina Medical Group, Inc.40
Unknown
Not Applicable
The Pathogenesis of Human Senile CataractCataractNCT03907358Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine20