The Pathogenesis of Age-related Cataract
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Characterization of miRNA in micro-scale human aqueous humor
研究概览
简要总结
To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.
详细描述
Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 94 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery.
排除标准
- •Patients whose cataracts need not be operated
- •Patients with any contraindications to cataract surgery
- •Patients are unwilling to undergo cataract surgery
结局指标
主要结局
Characterization of miRNA in micro-scale human aqueous humor
时间窗: 12 month
method development for miRNA detection in aqueous humor
Study of cataract by genomics, transcriptomics, and proteomics approaches
时间窗: 36 month
detect histone H3 lysine 4 trimethylation (H3K4me3) of aqueous humor of cataract patients by genomics, transcriptomics, and proteomics methods
Favored amplification recovery via protection-chromatin immunoprecipitation-Seq of human eye tissue samples
时间窗: 24 month
low-cell-number epigenome profiling for study of cataract
次要结局
未报告次要终点
研究者
Haidong Zou
Professor
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine