Association Between Serum Gonadal Hormone, Gonadotropin and Cardiovascular Events
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 8,000
- 试验地点
- 1
- 主要终点
- Cardiovascular disease mortality
研究概览
简要总结
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated. On the other hand, the dramatic increase in gonadotropin level didn't drew much attention when talking about the increased risk of cardiovascular disease during menopausal transition. This study aim to investigate the association between gonadal hormone, gonadotropin and long-term cardiovascular events.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female with intact uterus and at least one ovary
- •Aged of 18 to 75 years old;
排除标准
- •Pregnancy or lactation women;
- •Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome or other endocrinal and metabolic disorders that known to compromise hypothalamic-pituitary-gonadal function;
- •Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies;
- •Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health;
- •Obviously poor compliance.
结局指标
主要结局
Cardiovascular disease mortality
时间窗: Measured after 10 years of follow-up
Total deaths from cardiovascular disease over a given period of time
Rate of first cardiovascular disorder events
时间窗: Measured after 10 years of follow-up
Total incidence rate from cardiovascular disorder over a given period of time
All-cause mortality
时间窗: Measured after 10 years of follow-up
Total deaths from all causes over a given period of time
次要结局
- Change in serum lipid levels(Measured at baseline, and every 2 years during the 10-year follow-up period)
- Number of participants that diagnosed with metabolic syndrome(Measured at baseline, and every 2 years during the 10-year follow-up period)
- Number of participants that diagnosed with non-alcoholic fatty liver disease(Measured at baseline, and every 2 years during the 10-year follow-up period)
- Change in thickness of blood vessel wall(Measured at baseline, and every 2 years during the 10-year follow-up period)
研究者
Jia-jun Zhao
Professor
Shandong Provincial Hospital