Brain stimulation, aging and cognition: Investigating neuroplasticity and cognitive enhancement following brain stimulation in amnestic mild cognitive impairment.

Not Applicable

Completed

• Conditions: Amnestic Mild Cognitive Impairment; Neurological - Neurodegenerative diseases; Neurological - Alzheimer's disease; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12615000886583
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-08-25
• Study Completion: 2017-01-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

a) Subjective and objective memory complaints. Objective memory complaints are defined as >1.5SDs below the mean on visual or verbal memory tasks, OR
b) Healthy adults aged between 18 - 35 years OR 56 - 80 years with no cognitive complaints.

Exclusion Criteria

* History of seizures or neurological disorders
* Current psychiatric diagnoses, alcohol or substance dependence
* Left-handed
* Presence of metal in head
* Women who are currently pregnant or lactating
* Individuals taking benzodiazepines or acetyl cholinesterase inhibitors

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
-back task (accuracy and reaction time)<br>[30 minutes post final block of stimulation. ];TMS-EEG evoked potential amplitudes which provide an indication of prefrontal cortex activity in response to tDCS. [5 and 20 minutes post the final block of stimulation ]

Secondary Outcome Measures

Name	Time	Method
EEG oscillations across the scalp in areas relevant to network activity. [5 and 20 minutes post the final block of stimulation. ]