A comparative study of the effects of two drugs, atorvastatin and glucophage, on plasma insulin resistance and follicular fluid changes in women with polycystic ovary syndrome.

Phase 3

Recruiting

Conditions: Women with polycystic ovary syndrome.
E28.2

Registration Number: IRCT20240122060763N1

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 50

Inclusion Criteria

According to the Rotterdam criteria (the presence of two criteria for the diagnosis of polycystic ovaries 1- oligomenorrhea or amenorrhea 2- clinical or laboratory findings of hyperandrogenism 3- the presence of polycystic ovaries in ultrasound examination) the diagnosis of PCOS has been confirmed in them
Age 18-40 years
Absence of thyroid disorder, Cushing's syndrome, hyperprolactinoma
Absence of kidney disease, liver disease, diabetes, lipid profile disorder
No history of cardiovascular disease and blood pressure
Not using ovarian stimulation drugs or hormonal drugs in the last 3 months
Not using insulin-sensitive drugs or lipid profiles in the last 3 months
not smoking
non-alcoholic
No use of addictive substances
Not having breast cancer
Absence of medicinal contraindications
Absence of malabsorption
Having a minimally abnormal amount of insulin resistance

Exclusion Criteria

Body mass more than 30 kg/m2
Body mass less than 19 kg/m2

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of insulin resistance is measured based on the HOMA index. The amount of fasting insulin is multiplied by the amount of fasting sugar and the resulting number is divided by 22.5, which is equal to 1 in normal people. Timepoint: The amount of insulin resistance is measured once before the intervention in two groups and again after the intervention in two groups. Method of measurement: Measuring insulin resistance: the amount of fasting insulin is multiplied by the amount of fasting sugar and the resulting number is divided by 22.5, which is equal to 1 in normal people.

Secondary Outcome Measures