Intrauterine delivery of Dexamethasone for repeated implantation failure: a RCT

Not Applicable

Conditions: Patients with repeated implantation failure.

Registration Number: IRCT20200502047261N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 60

Inclusion Criteria

Age under 40 years
(AMH) above one
At least twice the previous ART by transferring at least six grade one embryos
Healthy uterine cavity in ultrasound and hysteroscopy (lack of uterine anomaly, endometrial polyp, uterine myoma)
Absence of endocrinopathy and autoimmune and thrombophilic diseases
Normal karyotype
Absence of severe male infertility
Absence of moderate or severe endometriosis
Absence of a specific cause for implantation in previous ARTs
Absence of hydrosalpenx

Exclusion Criteria

Age over 40 years
(AMH) below one
Abnormal uterine cavities on ultrasound and hysteroscopy (with uterine anomalies, endometrial polyps, uterine myomas)
Endocrinopathy and autoimmune and thrombophilic diseases
Abnormal karyotype
Severe male infertility
Existence of a specific cause of non-implantation in previous ARTs
Existence of hydrosalpinx
Severe or moderate endometriosis

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pregnancy. Timepoint: According to the random list, patients are divided into intervention and control groups.In both groups, after basic ultrasound on the second day of the cycle, the ART cycle begins, and ovarian stimulation information is recorded for each patient. In patients in the 9 and 12 days of intramuscular injection of dexamethasone 600µL (5mg / ml) with a fetal transfer catheter, the intervention is performed slowly.In patients with the control group, the same normal volume of sterile saline is prescribed.Both groups are followed by transvaginal ultrasound while taking ART.When at least two follicles are seen, 10,000 HCG units are injected and 36 hours later the pancreas is transplanted under vaginal ultrasound. The ultrasound is performed two weeks later and the pregnancy sac is examined. Method of measurement: Pregnancy test(ßHCG).

Secondary Outcome Measures