Comparative study of intravenous bolus doses of nalbuphine with fentanyl in attenuating hemodynamic response to laryngoscopy in patients undergoing nasal intubation for oral and maxillofacial surgery (OMFS) under general anesthesia
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Compare the efficacy between nalbuphine and fentanyl in attenuating hemodynamic response to laryngoscopy and nasal intubation.
研究概览
简要总结
General Anesthesia administration involves laryngoscopy and endotrachial intubation which are associated with the pressor response and can lead to tachycardia, hypertension and arrhythmias, which can be deleterious in both healthy and compromised patients and hence response needs to be suppressed.Nasal intubation is the commonest endotracheal intubation method practiced during general anaesthesia in oral and maxillofacial surgeries. This study is designed to compare the efficacy of nalbuphine and fentanyl in attenuation of haemodynamic response in patients undergoing nasal intubation under general anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Double Blind Double Dummy
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Undergoing nasal intubation in oral and maxillofacial surgery.
- •Patient belonging to American society of Anaesthesiologist physical 1 and 2.
排除标准
- •Age>60 or <18 Preoperative hypertension, coronary artery disease (CAD), cardiac conduction defects, congenial heart disease, hemodynamic instability and associated comorbidity.
- •Obesity ( body mass index >30 kg per square meter).
- •Mouth opening less than or equal to 2.5 fingers or inability to do laryngoscopy.
- •MPG grade
- •Patients with nasal fracture.
结局指标
主要结局
Compare the efficacy between nalbuphine and fentanyl in attenuating hemodynamic response to laryngoscopy and nasal intubation.
时间窗: Intraoperatively
次要结局
- Compare Post operative sedation(Compare post operative pain.)