Comparison of Intravenous Versus Nebulized Dexmedetomidine for hemodynamic stability after intubation

Phase 4

Not yet recruiting

• Conditions: Measurement and Monitoring,

• Registration Number: CTRI/2025/06/089300
• Lead Sponsor: Government medical College, BARODA

Brief Summary

General anaesthesia with muscle relaxant using control ventilation involve laryngoscopy and tracheal intubation

increase in sympathetic activity noted during laryngoscopy and endotracheal incubation

There is a necessity to Blunt this response to prevent deleterious effect like LVF MI increase ICP arrhythmia.

highly selective dexmedetomidine can be used in prevent this effect

Dexmedetomidine block release of catecholamines and inhibit sympathetic activity and decrease hemodynamic response to laryngoscopy and intubationNebulized dexmedetomidine may provide a favourable alternative to intravenous route for attenuation of sympathoadrenal stress response to intubation without any significant sideeffects with added advantage of preventing postoperative sore throat

Detailed Description

Not available

Study Timeline

• Study Start: 2025-01-07
• Last Update Posted: 2025-06-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

A) Patients posted for elective surgery under general anesthesia requiring endotracheal intubation B) Age: 18- 60 years C)Gender: Either gender D)ASA I, II and III.

Exclusion Criteria

Patient refusal Dexmedetomidine allergy Preoperative sore throat or upper respiratory infection Significant cardiac pulmonary or hepatorenal disease Body mass index more then thirty kg per meter swerve Predictive difficult airway Pregnant patient.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Nebulized dexmedetomidine may provide a favourable alternative to intravenous route for attenuation of sympathoadrenal stress response to intubation	Till 10 minutes after intubation

Secondary Outcome Measures

Name	Time	Method
Preventing post operative sore throat	Post operative 24 hour

Trial Locations

Locations (1)

Government medical College baroda; 🇮🇳 Vadodara, GUJARAT, India

Government medical College baroda

🇮🇳Vadodara, GUJARAT, India

Dr Parmar Bharat

Principal investigator

9978292173

drbharat740@gmail.com