Comparison of fentanyl and nalbuphine in attenuating blood pressure and heart rate during laryngoscopy in patients undergoing general anaesthesia.

Phase 3

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2024/04/065626

Brief Summary

General Anesthesia administration involves laryngoscopy and endotrachial intubation which are associated with the pressor response and can lead to tachycardia, hypertension and arrhythmias, which can be deleterious in both healthy and compromised patients and hence response needs to be suppressed.Nasal intubation is the commonest endotracheal intubation method practiced during general anaesthesia in oral and maxillofacial surgeries. This study is designed to compare the efficacy of nalbuphine and fentanyl in attenuation of haemodynamic response in patients undergoing nasal intubation under general anaesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-19
• Last Update Posted: 2024-09-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Undergoing nasal intubation in oral and maxillofacial surgery.
• Patient belonging to American society of Anaesthesiologist physical 1 and 2.

Exclusion Criteria

• Age>60 or <18 Preoperative hypertension, coronary artery disease (CAD), cardiac conduction defects, congenial heart disease, hemodynamic instability and associated comorbidity.
• Obesity ( body mass index >30 kg per square meter).
• Mouth opening less than or equal to 2.5 fingers or inability to do laryngoscopy.
• MPG grade 4.
• Patients with nasal fracture.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare the efficacy between nalbuphine and fentanyl in attenuating hemodynamic response to laryngoscopy and nasal intubation.	Intraoperatively

Secondary Outcome Measures

Name	Time	Method
Compare Post operative sedation	Compare post operative pain.

Trial Locations

Locations (1)

Faculty of Dental Sciences,IMS, BHU; 🇮🇳 Varanasi, UTTAR PRADESH, India

Faculty of Dental Sciences,IMS, BHU

🇮🇳Varanasi, UTTAR PRADESH, India

Shubhangi

Principal investigator

7903701788

sipushubhangi@gmail.com