Risk Factor Analysis and Predictive Modeling for Necrotizing Skin Infections in Venomous Snakebite Patients: A Multicenter Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Incidence of Necrotizing Skin Infections
研究概览
简要总结
This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model. Clinical data from 99 patients treated between January 2020 and April 2024 at three hospitals in Guangdong Province, China, were analyzed.
详细描述
Venomous snakebites are a significant public health issue, particularly in tropical and subtropical regions like southern China. Necrotizing skin infections are a severe but relatively rare complication of venomous snakebites, often resulting from delayed treatment and bacterial invasion. This study retrospectively analyzed clinical data from 99 patients with venomous snakebites treated at three hospitals in Guangdong Province between January 2020 and April 2024. The primary objective was to identify the major risk factors associated with the development of necrotizing skin infections and to build a predictive model to assist in clinical decision-making.
The study included male and female patients aged 14 years and older. Patients with incomplete medical records, long-term use of immunosuppressants, or underlying immunodeficiency diseases were excluded. Multivariate logistic regression identified the Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels as significant independent predictors of necrotizing infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of venomous snake bites confirmed according to major international clinical guidelines and expert consensus.
- •Availability of complete case data.
- •Provision of written informed consent by the patients or their legal guardians.
排除标准
- •Age less than 14 years.
- •Long-term use of immunosuppressants or corticosteroids.
- •Presence of concurrent immunodeficiency diseases (e.g., HIV positive).
- •Severe malnutrition.
- •Incomplete medical records.
研究组 & 干预措施
Necrotizing Skin Infections Group
This cohort includes patients who developed necrotizing skin infections following venomous snakebites. These patients were treated at three hospitals in Guangdong Province between January 2020 and April 2024. The study aims to identify key risk factors, including Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels, that are associated with the development of necrotizing skin infections in these patients.
干预措施: Antivenom Serum (Drug)
Necrotizing Skin Infections Group
This cohort includes patients who developed necrotizing skin infections following venomous snakebites. These patients were treated at three hospitals in Guangdong Province between January 2020 and April 2024. The study aims to identify key risk factors, including Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels, that are associated with the development of necrotizing skin infections in these patients.
干预措施: Wound Debridement (Procedure)
Non-Infection Group
This cohort includes patients who did not develop necrotizing skin infections after venomous snakebites. These patients were treated at the same three hospitals between January 2020 and April 2024. The cohort serves as a control group to compare against the infection group, helping to determine risk factors associated with necrotizing skin infections in snakebite patients.
干预措施: Antivenom Serum (Drug)
Non-Infection Group
This cohort includes patients who did not develop necrotizing skin infections after venomous snakebites. These patients were treated at the same three hospitals between January 2020 and April 2024. The cohort serves as a control group to compare against the infection group, helping to determine risk factors associated with necrotizing skin infections in snakebite patients.
干预措施: Wound Debridement (Procedure)
结局指标
主要结局
Incidence of Necrotizing Skin Infections
时间窗: 30 days from admission or until discharge.
The primary outcome measure is the incidence of necrotizing skin infections among venomous snakebite patients within the study period. Necrotizing infections were identified based on clinical diagnostic criteria, including tissue necrosis, infection severity, and systemic symptoms.
次要结局
- Hospital Length of Stay(From hospital admission until discharge, typically ranging between 1 and 30 days.)
研究者
Zhibin Xu
Professor
Guangzhou Institute of Respiratory Disease