Effect of Magnesium sulfate in organophosphorus poisoning

Phase 3

Conditions: Condition 1: organophosphorus poisoning. Condition 2: organophosphorus poisoning.
Poisoning by drugs primarily affecting the autonomic nervous system
Organophosphate and carbamate insecticides

Registration Number: IRCT2016092823552N10

Lead Sponsor: Arak University of Medical Sciences, Vice Chancellor for Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 80

Inclusion Criteria

Age 18 to 65 years old; patients with acute organophosphorus poisoning who do not receive medical care in another medical center; Taking time less than 2 hours after poisoning; Patients satisfaction.
Exclusion criteria: Unwillingness to participate in the study; Concomitant use of drugs or other substance accidentally or as a suicidal attempt; History of severe complications or sensitivity to Magnesium sulfate; History of heart block, Myocardial infarction, severe renal failure, Hepatitis and Addison's disease; Patients death.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tracheal secretions. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Respiratory crackle. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Size of pupils. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Deep tendon reflexes. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Salivary secretions. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Fasciculation severity. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.

Secondary Outcome Measures

Name	Time	Method
iver function test. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Creatinine. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Serum level of electrolytes. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Blood sugar. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Arterial blood gasses. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.