Compare Sudden Stopping and Weaning of Anticholinergics in Recurrence of OAB Symptoms
- Registration Number
- NCT04064619
- Lead Sponsor
- Beni-Suef University
- Brief Summary
Our study included 60 patients with idiopathic OAB and treated with solifenacin 5mg twice daily for one month. After improvement of their condition, we divided the responders into 2 groups, group I stopped the drug suddenly, while group II underwent gradual weaning of the drug.
- Detailed Description
We started an open-label, prospective, two-arm, randomized controlled trial at Beni-Suef University, from January 2018 to January 2019, including 60 patients suffering from OAB symptoms. Patients were recently diagnosed with idiopathic OAB which was not treated prior to enrollment. All participants signed written informed consents. The study protocol was approved by the ethics committee of our faculty. Patients were allocated into 2 equal groups (30 patients in each group) according to a computer-generated random numeric table after exclusion of those who are not eligible or refused to be included in the study
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- OAB patients.
- Recently diagnosed.
- Previous trials of treatment
- UTI, stones, tumors, or Infravesical obstruction.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sudden stopping Solifenacin Succinate 5 MG patients were followed up after 1 and 3 months from stopping the drug, Weaning Solifenacin Succinate 5 MG patients were followed up after 1and 3 months from the end of gradual weaning
- Primary Outcome Measures
Name Time Method improvement 1 month decrease voiding times
- Secondary Outcome Measures
Name Time Method recurrence of symptoms 3 months increase in voiding times after improvement
Trial Locations
- Locations (1)
Beni-Suef University
🇪🇬Banī Suwayf, Beni-Suef, Egypt