Factors affecting outcomes after supermicrosurgical lymphovenous anastomosis in a defined patient populatio

• Conditions: I89.0; Lymphoedema, not elsewhere classified

• Registration Number: DRKS00017413
• Lead Sponsor: niversitätsmedizin Göttingen

Brief Summary

BACKGROUND:The optimal surgical treatment for lymphedema is still subject of intensive research. Therefore, it is vital to investigate what significance lymphovenous anastomosis (LVA) has in this context. OBJECTIVE:This study aims to determine the short- and long-term results as well as the most important factors that can improve outcomes after LVA. METHODS:This study includes a complete data set of 26 patients who received LVA for a therapy-resistant lymphedema. Patients were followed up for an average of 23 months. RESULTS:50% of the patients reported a subjective improvement. Without conservative treatment after the operation the patients showed significant better results (100% vs. 40.9%, p = 0.030). The localization of lymphedema as well as the region of LVA had a significant influence. In patients with lymphedema affecting the entire leg, symptom improvement was significantly lower (35.3% vs. 77.8%, p = 0.039). Patients who received LVA in an upper limb show a significantly higher improvement in symptoms than patients who received LVA in a lower limb (100% vs. 30%, p = 0.021). CONCLUSIONS:We identified factors with a significant influence on the outcome of patients after receiving LVA. Patients with early-stage upper extremity lymphedema seem to benefit most from this procedure.

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-09-15
• Study Start: 2019-06-25
• Results First Posted: 2019-11-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

All adult patients who are able and willing to consent and who have received lymphovenous anastomoses for an existing lymphedema after exhaustion of the conservative therapy measures.

Exclusion Criteria

Patients with liver dysfunction, known allergy to indocyanine green, sodium iodide, iodine, hyperthyroidism, focal and diffuse thyroid autonomy, pregnancy and lactation.

Study & Design

• Study Type: observational
• Study Design: Not specified