Supermicrosurgical Lymphvenous Bypass Intervention for Treatment

• Conditions: Lymphedema of Leg
• Interventions: Other: Antegrade and retrograde anastomoses; Other: Antegrade-only anastomoses

• Registration Number: NCT05270629
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

Background: In addition to antegrade anastomosis, retrograde anastomosis has been thought to offer further improvements after lymphaticovenous anastomosis (LVA) by bypassing the retrograde lymphatic flow. However, this concept has yet to be validated. The aim of this study was to determine the impacts on outcomes of performing both retrograde and antegrade anastomosis, as compared to antegrade-only anastomosis for treating lower limb lymphedema.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-06
• Status Verified: 2022-02
• Study First Submitted: 2022-02-28
• Study First Submitted QC: 2022-02-28
• Last Update Submitted: 2022-02-28
• Study First Posted: 2022-03-08
• Last Update Posted: 2022-03-08
• Primary Completion: 2022-08-31
• Study Completion: 2022-09-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

• Lower limb lymphedema patients.

Exclusion Criteria

• Patients who have had previous LVA, liposuction, or excisional therapy such as the Charles procedure were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Lower limb lymphedema patients	Antegrade and retrograde anastomoses	This was a retrospective cohort propensity score-matched study. Patients with lower limb lymphedema were enrolled.
Lower limb lymphedema patients	Antegrade-only anastomoses	This was a retrospective cohort propensity score-matched study. Patients with lower limb lymphedema were enrolled.

Primary Outcome Measures

Name	Time	Method
Magnetic resonance volumetry	6 months after LVA	Magnetic resonance volumetry was used for outcome assessments. The primary endpoint was the volume change at 6 months after LVA.

Trial Locations

Locations (1)

Kaohsiung Chang Gung Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan