Role of Supermicrosurgical LVA for Lower Limb Lymphedema

Completed

• Conditions: Lymphedema
• Interventions: Other: Vascularized lymph node flap transfer; Other: Patients without prior lymphedema surgery

• Registration Number: NCT04698707
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

Vascularized lymph node flap transfer (VLNT) was believed to be the treatment of choice for moderate-to-severe lymphedema. Recent publications have supported the use of supermicrosurgical lymphaticovenous anastomosis (LVA) for treating severe lymphedema. This study hypothesizes whether LVA can be performed on post-VLNT patients seeking further improvement.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-28
• Primary Completion: 2020-10-05
• Study Completion: 2020-11-19
• Status Verified: 2021-01
• Study First Submitted: 2021-01-05
• Study First Submitted QC: 2021-01-05
• Last Update Submitted: 2021-01-05
• Study First Posted: 2021-01-07
• Last Update Posted: 2021-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 131

Inclusion Criteria

• From November 2014 to January 2019
• Lower limb lymphedema patients

Exclusion Criteria

• Patients who have had previous LVA, liposuction, or excisional therapy such as the Charles procedure were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
lower limb lymphedema patients	Patients without prior lymphedema surgery	This retrospective cohort study enrolled 131 lower limb lymphedema patients including 10 patients who have received VLNT as their primary lymphedema surgery showing minimal post-VLNT improvement (Group I) and 121 patients without previous lymphatic surgery (Group II).
lower limb lymphedema patients	Vascularized lymph node flap transfer	This retrospective cohort study enrolled 131 lower limb lymphedema patients including 10 patients who have received VLNT as their primary lymphedema surgery showing minimal post-VLNT improvement (Group I) and 121 patients without previous lymphatic surgery (Group II).

Primary Outcome Measures

Name	Time	Method
Magnetic resonance volumetry	6 months after LVA	Magnetic resonance volumetry was used for measuring preoperative and postoperative volume changes at least 6-month after LVA.

Trial Locations

Locations (1)

Kaohsiung Chang Gung Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan