Comparison of computed tomography scans (CT) and clinical risk tools to standard dual-energy X-ray absorptiometry scans (DXA) to detect osteoporosis and predict spinal fracture in lung cancer screening participants
- Conditions
- OsteoporosisVertebral fractureLung cancer screeningQuantitative computed tomographyDual-energy x-ray absorptiometryMusculoskeletal - OsteoporosisMusculoskeletal - Other muscular and skeletal disordersRespiratory - Other respiratory disorders / diseasesCancer - Lung - Non small cellCancer - Lung - Small cell
- Registration Number
- ACTRN12621001367831
- Lead Sponsor
- The University of Queensland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 94
Participants enrolled in the ILST (men and women, aged 55-80 years, current or former smokers quit <15 years prior, >=30 pack-year smoking history and/or estimated lung cancer risk >=1.51% based on the PLCOm2012 risk prediction model, ECOG performance status 0 or 1) who are also volunteers in the ILST osteoporosis sub-study
-Participants who provide written consent.
Exclusion criteria per ILST:
• Clinical symptoms suspicious for lung cancer
• Concurrent major medical illness (Any medical condition that, in the investigator’s opinion, may jeopardize the subject’s safety during participation in the study or mean that the subject is unlikely to benefit from screening due to shortened life expectancy)
• Previous lung cancer
• Other non-curatively treated non-pulmonary cancer or <5 years cancer-free if previous cancer
• Pneumonia/bronchitis requiring antibiotics within previous 12 weeks
• CT chest within the last 2 years
• Received chemotherapy/other cytotoxic drugs within the last 6 months
• Pregnancy
• Unwilling/unable to have chest CT
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method