Determining efficacy of smoke cessation on tuberculosis treatment

Not Applicable

• Conditions: tuberculosis.; Respiratory tuberculosis, bacteriologically and histologically confirmed

• Registration Number: IRCT2013062613783N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

current manufactured cigarette smokers will be diagnosed with active pulmonary TB: either sputum smear-positive or smear-negative, based on classification from WHO treatment guidelines; classify under treatment Category I (new TB cases) ; patients of both sexes, aged 18 years and above; speaking the Persian language.
Exclusion criteria: having extra pulmonary TB only (involving CNS, pericardium, adrenal etc) ; they have multi-drug resistant tuberculosis at diagnosis ; they are living with or newly diagnosed with HIV/AIDS ; they are active IV drug abuser ; they are classified as Category II (relapse, treatment failure, and treatment after default) or Category III (chronic TB) ;they fulfill the eligibility criteria, but unwilling to participate in the study or unable to understand the contents of the informed consent form.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tuberculosis treatment outcome. Timepoint: 2,4,6 months. Method of measurement: sputum smear.

Secondary Outcome Measures

Name	Time	Method
Smoke cessation. Timepoint: 2-4-6 months. Method of measurement: urine cotenine test.;Immunologic response(phagocytes capacity uptake and IL-8 amount). Timepoint: 3 months. Method of measurement: flow cytometry.