Measuring rTMS-induced Neuroplasticity With EEG Steady-state Visual-evoked Potentials

Not Applicable

• Conditions: Repetitive Transcranial Magnetic Stimulation; Visual Cortical Plasticity; Visual Attention
• Interventions: Device: repetitive transcranial magnetic stimulation

• Registration Number: NCT05853939
• Lead Sponsor: Stanford University

Brief Summary

The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection paradigms as a behavioral measure of rTMS effects, and 3) to investigate how visual spatial attention augments or suppresses the neuroplastic impact of rTMS. Participants will observe visual stimuli on a screen while allocating their attention to different parts of the visual field and making responses when they observe changes in the visual stimuli. rTMS is performed to visual cortex using MRI-retinotopy neuronavigation. Then the visual task paradigm is performed again.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-02
• Study First Submitted QC: 2023-05-02
• Study First Posted: 2023-05-11
• Study Start: 2023-07-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-18
• Last Update Posted: 2024-04-22
• Primary Completion: 2027-05
• Study Completion: 2027-05

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Men and women, ages 18 to 65
• Must comprehend English well to ensure adequate comprehension of the EEG and TMS instructions, and of clinical scales
• Left- or Right-handed
• No current or history of neurological disorders
• No seizure disorder or risk of seizures

Exclusion Criteria

• Those with a contraindication for MRIs (e.g. implanted metal)

  • Any unstable medical condition
  • History of head trauma with loss of consciousness
  • History of seizures
  • Neurological or uncontrolled medical disease
  • Active substance abuse
  • Diagnosis of psychotic or bipolar disorder
  • Currently taking medications that substantially reduce seizure threshold (e.g., bupropion, olanzapine, chlorpromazine, lithium)
  • Currently pregnant or breastfeeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Visual Cortex, 10 Hz rTMS, Unattended	repetitive transcranial magnetic stimulation	-
Visual Cortex, 1 Hz rTMS, Attended	repetitive transcranial magnetic stimulation	-
Visual Cortex, 1 Hz rTMS, Unattended	repetitive transcranial magnetic stimulation	-
Visual Cortex, 10 Hz rTMS, Attended	repetitive transcranial magnetic stimulation	-
Visual Cortex, Sham, Attended	repetitive transcranial magnetic stimulation	-
Visual Cortex, Sham, Unattended	repetitive transcranial magnetic stimulation	-

Primary Outcome Measures

Name	Time	Method
post-rTMS change in ssVEP Response Amplitude	60 minutes	Change in ssVEP contrast-response amplitude after rTMS
post-rTMS change in visual contrast perceptual sensitivity	60 minutes	change in visual psychometric threshold across contrasts after rTMS

Trial Locations

Locations (1)

Stanford University; 🇺🇸 Stanford, California, United States