Impact of Priming the Infusion System on the Performance of Target-controlled Infusion of Remifentanil
- Conditions
- Intravenous Drug Usage
- Registration Number
- NCT01477905
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
The investigators attempted to determine an adequate priming volume for our infusion system, and investigated the extent of a possible delay of the drug effect, that would result from mechanical defects of the infusion system, with or without priming the infusion system, using direct gravimetrical measurements of virtual infusate amounts during target controlled infusion of 2 remifentanil diluents.
- Detailed Description
Priming the infusion system (PRIMING) was performed using an evacuation of 2.0 ml to the atmosphere prior to Target-controlled Infusion (TCI). Forty eight TCI, using 50 μg/ml or 20 μg/ml of remifentanil diluents, were performed targeting 4.0 ng/ml of effect site concentration (Ceff), with or without PRIMING. Using simulations, the gravimetrical measurements of the delivered infusates reproduced actual predicted concentrations.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
- electric medical records of the patients who had undergone general anaesthesia
- body weight exceeding 20% of ideal body weight
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method delivered infusates of remifentanil base line from 30 min of TCI was maintained For targetting an effect-site concentration (Ceff) of 4.0 ng/ml, were randomly performed using 50 μg/ml (Remi50) or 20 μg/ml (Remi20) of remifentanil, and with or without PRIMING, TCI data files, including predicted plasma (Cp-proper), and effect-site (Ceff-proper) concentrations were saved
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ajou University School of Medicine
🇰🇷Suwon, Korea, Republic of
Ajou University School of Medicine🇰🇷Suwon, Korea, Republic of