Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness

Not Applicable

Recruiting

• Conditions: Sudden Deafness
• Interventions: Procedure: Stellate ganglion block; Procedure: Facial and glossopharyngeal nerve blocks; Drug: Mecobalamin Tablets

• Registration Number: NCT05623384
• Lead Sponsor: Zhuan Zhang

Brief Summary

Sudden deafness is a sudden, unexplained sensorineural hearing loss of ≥20 dBHL in at least two adjacent frequencies within 72 h. It may be accompanied by tinnitus, a sense of ear congestion, vertigo and other Symptoms.Stellate ganglion block increases the blood flow and blood velocity in the inner ear, keeping the body's vegetative, endocrine and immune functions normal.The branches of the facial and linguopharyngeal nerves are connected to the inner ear, and local injection can nourish the nerves and improve local circulation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-11
• Study First Submitted: 2022-11-13
• Study Start: 2022-11-14
• Study First Submitted QC: 2022-11-18
• Last Update Submitted: 2022-11-18
• Study First Posted: 2022-11-21
• Last Update Posted: 2022-11-21
• Primary Completion: 2023-09-30
• Study Completion: 2023-09-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Meet the diagnostic criteria for sudden deafness established by the Editorial Board of the Chinese Journal of Otolaryngology, Head and Neck Surgery and the Chinese Society of Otolaryngology, Head and Neck Surgery
• Age 18 to 80 years
• ASA classification Ⅰ~Ⅲ grade

Exclusion Criteria

• Acoustic conductance test, vestibular function test, cranial MRI, etc. suggest organic disease
• People with coagulation disorders or on anticoagulation therapy
• Infection at the puncture site
• Severe systemic diseases that cannot cooperate with treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Stellate ganglion block combined with facial and glossopharyngeal nerve block group	Stellate ganglion block	-
Stellate ganglion block combined with facial and glossopharyngeal nerve block group	Facial and glossopharyngeal nerve blocks	-
Stellate ganglion block combined with facial and glossopharyngeal nerve block group	Mecobalamin Tablets	-
Stellate ganglion block group	Mecobalamin Tablets	-
Stellate ganglion block group	Stellate ganglion block	-
Control group	Mecobalamin Tablets	-

Primary Outcome Measures

Name	Time	Method
Mean Hearing Threshold (PTA)	Baseline (Before treatment)，1 month and 2 months after treatment	The average of hearing thresholds at six frequencies (250, 500, 1000, 2000, 4000, and 8000 Hz) was recorded as the mean hearing threshold (PTA).

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China