The effect of mechanical ventilation during cardiopulmonary bypass surgery in adult cardiac valve surgery on inflammatory responses and pulmonary functio

Not Applicable

Recruiting

• Conditions: Diseases of the respiratory system.; Acute respiratory failure; J96.0

• Registration Number: IRCT20211026052875N1
• Lead Sponsor: Rajaie Cardiovascular, Medical and Research Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

?All adult patients with age >35y undergoing elective cardiac valve surgery

Exclusion Criteria

patients undergoing emergency surgery
Patients undergoing congenital heart surgery
Patients undergoing third and more valve resections
Patients with coagulation disease
Patients undergoing dialysis
Patients with pulmonary problems such as COPD who are in stage one and four due to FEV1 ( stage1:mild FEV1=80%? stage2:moderate FEV1 50-79%? stage3:severe FEV130-49% ? stage 4: very severe FEV1 =30% )
Patients with fractional ejection less than 35%,
Patients who transfer to the ICU with open sternum
In this study, if the surgeon's vision decreases during cardiac surgery due to continued mechanical ventilation, the ventilation will stop and the patient will be excluded from the study
Patients who remain intubated for more than 12 hours after transfer to the ICU due to hemodynamic instability
patients who are transferred to the operating room for any reason

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammatory cytokines (IL-6, IL-8, IL-10,INT gamma,TNF alph). Timepoint: After induction of anesthesia and placement of the central vein; after separation from cardiopulmonary bypass; after extubation. Method of measurement: Inflammatory cytokines using venous blood samples in operation room and ICU.;Respiratory test. Timepoint: The day before surgery, the seventh day after surgery. Method of measurement: PFT and 6min Walking test before and after surgery.

Secondary Outcome Measures

Name	Time	Method
ength of stay in hospital and intensive care unit. Timepoint: After discharge from hospital. Method of measurement: length of stay in hospital and intensive care unit according to patient records.