The effect of nebulsied salbutamol and isotonic saline on exercise induced bronchoconstriction in elite skaters following a 1500 m race.

Completed

• Conditions: exercise induced asthma; Exercise inudeced airway obstruction; 10006436

• Registration Number: NL-OMON37214
• Lead Sponsor: Heerenveen Ziekenhuis, De Tjongerschans

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 41

Inclusion Criteria

Age between 18 and 35 years.;Elite speedskater.;Women: 1500 meter time below 2:10:00 minutes.
Men: 1500 meter time below 02:05:00 minutes.
These times should have been skated within a period of two months prior to study measurement.;Able to undergo reproducible lung function tests. Three-fold repetition of FEV1 measurements, with a mutual difference of maximal 5 percent.

Exclusion Criteria

Ultrasonic nebulization with Isotonic saline or tap water within 48 hours before testing.;FEV1 <70%.;Respiratory infection within 6 weeks prior to examination for which medication should be prescribed.;Use of short acting beta agonists 8 hours before testing.;Use of long acting beta agonists 24 hours before testing.;Use of leukotrineantagonists 36 hours before testing.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Reduced decrease in FEV1 after exercise by the verum group compared to placebo<br /><br>and control groups among elite skaters. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Analyze the change in exercise induced increase of airway resistance, measured<br /><br>with the FOT, after five minutes of treatment with salbutamol, 0.9% NaCl and<br /><br>controls.<br /><br>-Analyze the change in exercise induced decrease of airway reactance, measured<br /><br>with the FOT, after five minutes of treatment with salbutamol, 0.9% NaCl and<br /><br>controls.<br /><br>-Analyzing the change in the electro physiological activity of the respiratory<br /><br>muscle system, measured with EMG after five minutes of treatment with<br /><br>Salbutamol ,isotonic saline and controls. </p><br>