Improving enteral drug delivery with low molecular weight alginate oligosaccharides

• Conditions: secretory diarrhea; traveller's diarrhea; 10017966

• Registration Number: NL-OMON50130
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

Aged 18-55.
Enrollment by informed written consent

Exclusion Criteria

Coagulation disorders
Use of anticoagulants.
(Chronic) constipation. (As this may indicate aberrant intestinal ion and fluid
transport.)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>IC50 values of test compounds for inhibition of the ICM response of rectal<br /><br>biopsies.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>IC50 values of test compounds for inhibition of the ICM response in intestinal<br /><br>cell cultures (organoids).<br /><br>Histology of biopsies. Gene expression.</p><br>