Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold Images

Terminated

• Conditions: Lung Cancer
• Interventions: Other: Breath-Hold PET/CT image set

• Registration Number: NCT01109953
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The patient has been referred for an FDG PET/CT scan. FDG is a form of sugar that contains a small amount of radioactivity; it is used to see the size and possible spread of cancer in the body.

Pictures of the body are taken on a machine called a PET/CT scanner. The purpose of this current study is to see if we, the investigators, can take clearer pictures of the tumor than we could with our routine scan method. This would allow us to better see how FDG is picked up by the tumor. PET/CT is presently one of the best tools for detecting cancer and determining its spread in the body. However, due to breathing motion, PET and CT images may become blurred and the location of the tumor on CT and PET images may not match. We have developed a new method that enables us to reduce image blurring and to measure the tumor more accurately on PET images. In this study we want to compare two kinds of images: those from the standard PET/CT scan, and the PET/CT scan pictures taken with our new method.

If successful, we may use this new method for clinical routine in the future.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-04-20
• Study First Submitted QC: 2010-04-22
• Study First Posted: 2010-04-23
• Status Verified: 2012-03
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Last Update Submitted: 2012-03-15
• Last Update Posted: 2012-03-16

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Participant is capable of providing written consent.
• 18 years of age or older.
• Patient with a known or suspected FDG-avid malignancy in the torso

Read More

Exclusion Criteria

• none

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Breath-Hold PET/CT image	Breath-Hold PET/CT image set	In addition to the standard clinical PET/CT images, we will provide a breath-hold PET/CT image set, using the same PET data for both.

Primary Outcome Measures

Name	Time	Method
To determine if our breath-hold acquisition technique can be implemented in whole-body PET/CT scans.	at the time of scan	Because PET events not satisfying the breathing amplitude selection criteria will be dropped off the final image set, it will be necessary to increase the acquisition time for the FOV's covering the thorax area from 3 min/bed to 5 min/bed to compensate for the reduction in statistics. This should result in a total increase of \~6 min for the whole body scan.

Secondary Outcome Measures

Name	Time	Method
To determine if whole body PET/CT improves spatial matching of PET and CT	at the time of scan	to compare image quality, blurring, PET-to-CT mis-match, and lesion SUV of the standard PET images with the breath-hold ones.

Trial Locations

Locations (1)

Memorial Sloan-Kettering Cancer Center; 🇺🇸 New York, New York, United States