TCTR20160726002已完成2 期
Procalcitonin-guided Discontinuation of Antibiotic in Ventilator-Associated Pneumonia
-0 个研究点目标入组 50 人开始时间: 2016年7月26日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 100 Years（—）
- 性别
- All
入选标准
- •- Patients who were intubated and had received mechanical ventilation for at least 48 hours.
- •-age > 18 years
- •- clinical suspicion of VAP as defined by the ATS guidelines (new or progress pulmonary infiltration on CXR with two or more of the following: new or progress of fever; purulent sputum; WBC < 4,000 or > 12,000 cell/mm3); and simplified version of clinical pulmonary infection score > 6.
排除标准
- •- pregnant
- •- enrolled in another trial
- •- had little chance of survival
- •- had neutropenia (leukocyte counts <1000/µL or neutrophils <500/µL)
- •- had received immunosuppressants or long term corticosteroid therapy (≥ 0.5 mg/kg/day of prednisolone or equivalent dose for >1 month)
- •- had concomitant acquired immunodeficiency syndrome
- •- had a concomitant extrapulmonary infection diagnosed between days 1 and 3 that required prolonged (>8 days) antibiotic treatment or infection caused by confirmed non-bacterial pathogens such as fungus or virus.
- •- not received appropriate antibiotic within 3 days after enrollment
- •- had unfavorable clinical response after 7 days of appropriate antibiotic treatment as defined by one of the following: body temperature >37.8°C; shock or use of inotropes or vasopressors; clinical pulmonary infection score >6.
研究者
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