Procalcitonin-guided Discontinuation of Antibiotic in Ventilator-Associated Pneumonia

-0 sites50 target enrollmentJuly 26, 2016

Overview

No summary available.

Registry

who.int

Start Date

July 26, 2016

End Date

October 25, 2013

Last Updated

last year

Study Type

Interventional

Sex

All

Sponsor

•\- Patients who were intubated and had received mechanical ventilation for at least 48 hours.
•\-age \> 18 years
•\- clinical suspicion of VAP as defined by the ATS guidelines (new or progress pulmonary infiltration on CXR with two or more of the following: new or progress of fever; purulent sputum; WBC \< 4,000 or \> 12,000 cell/mm3\); and simplified version of clinical pulmonary infection score \> 6\.

•\- pregnant
•\- enrolled in another trial
•\- had little chance of survival
•\- had neutropenia (leukocyte counts \<1000/ÂµL or neutrophils \<500/ÂµL)
•\- had received immunosuppressants or long term corticosteroid therapy (â‰¥ 0\.5 mg/kg/day of prednisolone or equivalent dose for \>1 month)
•\- had concomitant acquired immunodeficiency syndrome
•\- had a concomitant extrapulmonary infection diagnosed between days 1 and 3 that required prolonged (\>8 days) antibiotic treatment or infection caused by confirmed non\-bacterial pathogens such as fungus or virus.
•\- not received appropriate antibiotic within 3 days after enrollment
•\- had unfavorable clinical response after 7 days of appropriate antibiotic treatment as defined by one of the following: body temperature \>37\.8Â°C; shock or use of inotropes or vasopressors; clinical pulmonary infection score \>6\.