Procalcitonin for discontinuation of antibiotic therapy in clinically diagnosed Ventilator Associated Pneumonia

niversity Hospital Basel (Switzerland)0 个研究点目标入组 100 人开始时间: 2006年9月1日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Intensive Care Unit (ICU) patients who are intubated and have been mechanically ventilated for at least 48 hours
•2. 18 years of age and older
•3. Clinical suspicion of VAP based on clinical and radiological criteria (new or progressive radiographic infiltrate) plus at least two of three clinical features:
•3.1. fever greater than 38°C
•3.2. leukocytosis or leucopenia
•3.3. purulent tracheal secretions

•1. Pregnancy
•2. Patients with coexisting, documented extrapulmonary infection diagnosed between days one and three that requires antibiotic therapy longer than three days
•3. Previous long-term corticosteroid therapy (more than or equal to 0.5 mg/kg per day of prednisolone or equivalent for more than one month)
•4. Severe immunosuppression (solid organ transplantation or stem cell transplant recipients, known Human Immunodeficiency Virus [HIV] infection, neutropenic patients and patients after chemotherapy)

发起方

niversity Hospital Basel (Switzerland)