Procalcitonin for discontinuation of antibiotic therapy in clinically diagnosed Ventilator Associated Pneumonia

niversity Hospital Basel (Switzerland)0 sites100 target enrollmentSeptember 1, 2006

Overview

No summary available.

Registry

who.int

Start Date

September 1, 2006

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity Hospital Basel (Switzerland)

•1\. Intensive Care Unit (ICU) patients who are intubated and have been mechanically ventilated for at least 48 hours
•2\. 18 years of age and older
•3\. Clinical suspicion of VAP based on clinical and radiological criteria (new or progressive radiographic infiltrate) plus at least two of three clinical features:
•3\.1\. fever greater than 38°C
•3\.2\. leukocytosis or leucopenia
•3\.3\. purulent tracheal secretions

•1\. Pregnancy
•2\. Patients with coexisting, documented extrapulmonary infection diagnosed between days one and three that requires antibiotic therapy longer than three days
•3\. Previous long\-term corticosteroid therapy (more than or equal to 0\.5 mg/kg per day of prednisolone or equivalent for more than one month)
•4\. Severe immunosuppression (solid organ transplantation or stem cell transplant recipients, known Human Immunodeficiency Virus \[HIV] infection, neutropenic patients and patients after chemotherapy)